Oxidative stress and endoplasmic reticulum stress are involved in palmitic acid-induced H9c2 cell apoptosis.

In this study, we explored the effects of PA on proliferation and apoptosis of H9c2 cardiomyocytes, and uncovered the signaling pathways involved in PA toxicity. Our study revealed induction of both oxidative and endoplasmic reticulum (ER) stresses and exacerbation of apoptosis in PA-treated H9c2 cells. Inhibition of oxidative stress by N-acetylcysteine reduced apoptosis and decreased ER stress in PA-treated H9c2 cells. Moreover, inhibition of ER stress by 4-phenyl butyric acid decreased apoptosis and attenuated oxidative stress. In summary, this study demonstrated that oxidative stress coordinates with ER stress to play important roles in PA-induced H9c2 cell apoptosis. PMID: 31064816 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31064816?dopt=Abstract

Source: Bioscience Reports - May 6, 2019 Category: Biomedical Science Authors: Yang L, Guan G, Lei L, Liu J, Cao L, Wang X Tags: Biosci Rep Source Type: research