Analysis of host cell binding specificity mediated by the Tp0136 adhesin of the syphilis agent Treponema pallidum subsp. pallidum

ConclusionsOur results show that Tp0136 facilitates differential level of binding to cell lines representing various host tissues, which highlights the importance of this protein in colonization of human organs byT.pallidum and resulting syphilis pathogenesis.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research

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This patient had a chordoid glioma at the right ventricle.1 He underwent gross total resection. Neurologic symptoms completely resolved after surgery. A low proliferation index with a Ki-67 of 3% was reported.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
The authors present a clinical case of a 48-year-old man who had a gross total resection of a chordoid glioma (CG), World Health Organization (WHO) grade 2, Ki-67 index 3%.1 Although classified as a WHO grade 2 neuroepithelial tumor, CGs, unlike conventional WHO grade 2 gliomas, are noninfiltrative and histologically consist of clusters and cords of epithelioid tumor cells within a mucinous stroma that commonly contains lymphoplasmacytic infiltrate. Extent of surgery has been the only intervention factor consistently associated with outcome.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
Chordoid glioma, a World Health Organization grade 2 glioma, originates within the intraventricular system and is characterized by its slow growth. Because it displays histopathologic/genetic features distinct from those of other low-grade gliomas,1 it is not representative of other low-grade gliomas reviewed in major randomized clinical trials. Molecularly, it has recently been defined by PRKCA D463H gene mutation with lack of gene alterations in IDH1, IDH2, TP53, ATRX, TERT, MGMT, and 1p19q, and it lacks TSC1 or TSC2 alterations typical of subependymal giant cell astrocytomas.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
A 48-year-old male presented with worsening gait instability, blurry vision, headache, and intermittent emesis over a 4-month period. Magnetic resonance imaging of the brain demonstrated a right ventricular mass at the foramen of Monro with associated obstructive hydrocephalus (Fig 1). The lesion was well circumscribed and nonenhancing and measured 1.9 cm × 1.9 cm × 2.1 cm with minimal surrounding edema. A computed tomography scan of the chest/abdomen/pelvis showed no evidence of extracranial disease.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
Conditions:   Type 1 Diabetes;   Continuous Glucose Monitoring;   Children;   Glucose Variability Intervention:   Sponsors:   University of Ljubljana, Faculty of Medicine;   International Society for Pediatric and Adolescent Diabetes;   Kinderkrankenhaus auf der Bult, Hannover, Germany;   Department of Pediatrcs, Endocrinology and Diabetes Medical University of Silesia in Katowice, Poland;   Pediatric Dia betes and Metabolic Disorders Unit, Regional Center for Pediatric Diabetes, University City Hosp...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Chen BS, Wang KY, Yu SQ, Zhang CB, Li GZ, Wang ZL, Bao ZS Abstract Gliomas are the most common type of primary brain tumor in adults with a high mortality rate. Low-grade gliomas progress to glioblastoma multiforme (GBM) in the majority of cases, forming secondary GBM (sGBM), followed by rapid fatal clinical outcomes. Protein tyrosine phosphatase receptor type Z1 (PTPRZ1)-MET proto-oncogene receptor tyrosine kinase (MET) (ZM) fusion has been identified as a biomarker for sGBM that is involved in glioma progression, but the mechanism of gliomagenesis and pathology of ZM-negative sGBM has remained to be full...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
When you take your car to Meineke, chances are you will get a muffler. Well, it seems when you take children to the emergency department or an urgent care center for abdominal pain due to constipation, chances are they will get an abdominal x-ray (AXR). Children discharged with a diagnosis of constipation account for up to 25% of cases seen in some emergency departments or urgent care centers, and as many as 30%-90% will have an AXR as part of their evaluation. Evidenced-based guidelines for the “Evaluation and Treatment of Functional Constipation in Infants and Children” published jointly by the North American...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
A new analysis by U.S. News&World Report ranks this Greater Cincinnati county among the healthiest communities in the United States.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
When the coronavirus hit the United States earlier this year, hospitals across the country were forced to quickly convert to crisis mode. Overnight, health systems transformed clinical and administrative operations to care for rising numbers of COVID-19 patients. Now, as the country slowly reopens and we move back to “normal,” hospitals again face a major reboot to regroup and recover. Those that meet this challenge successfully will survive. Many others will not. This month's Magnet® Perspectives column examines how Magnet hospitals are uniquely positioned to ride the waves and manage the chaos. What are t...
Source: JONA: The Journal of Nursing Administration - Category: Nursing Tags: Departments: Magnet® Perspectives Source Type: research
There is a growing interest outside the United States in obtaining Magnet® accreditation. King Fahad Specialist Hospital–Dammam became the 1st Ministry of Health hospital in the Kingdom of Saudi Arabia to be recognized as a Magnet®-accredited institution. Understanding the return on investment of Magnet accreditation is important and speaks to the value of Magnet for international hospitals. Data from a peer hospital will aid nurse executives when presenting the business case for Magnet accreditation.
Source: JONA: The Journal of Nursing Administration - Category: Nursing Tags: Articles Source Type: research
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