Analysis of host cell binding specificity mediated by the Tp0136 adhesin of the syphilis agent Treponema pallidum subsp. pallidum

ConclusionsOur results show that Tp0136 facilitates differential level of binding to cell lines representing various host tissues, which highlights the importance of this protein in colonization of human organs byT.pallidum and resulting syphilis pathogenesis.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research

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Publication date: Available online 15 February 2020Source: Trends in Anaesthesia and Critical CareAuthor(s): Sima Patel, Andrea Estevez, Nicholas Nedeff, Jose Gascon, Ilde LeeAbstractAcross the United States (U.S.), very few centers exist with an intensive care unit (ICU) solely dedicated to obstetrics (OB) and gynecology (GYN) patients. The management of obstetric patients, who are admitted to a general intensive care unit, can often be accompanied by a fair share of apprehension owing to the intricacy of care. Rather than discussing common obstetric emergencies and their management, we would like to call attention to bas...
Source: Trends in Anaesthesia and Critical Care - Category: Anesthesiology Source Type: research
Authors: Burris M, Miller E, Romero-Daza N, Himmelgreen D Abstract The aim of this study was to assess whether household food insecurity is associated with delayed or early menarche among girls in the United States. Thirty-six dyadic household interviews were conducted with mothers and adolescent girls. The interviews included a socio-demographic survey, the USDA Six-Item Short Form Household Food Security Survey Module, anthropometric measurements, and the self-administered Youth-Adolescent Food Frequency Questionnaire. Using non-parametric quantitative analyses, we examined the associations among food insecurity,...
Source: Ecology of Food and Nutrition - Category: Nutrition Tags: Ecol Food Nutr Source Type: research
This study examined age differences in associations among primary stressors (caregiver burden which includes hours of provided care and number of activities of daily living and instrumental activities of daily living performed), secondary stressors (financial and employment strains), and caregiver outcomes (emotional strain and physical strain). RESEARCH DESIGN: Using Pearlin's Stress Process Model (1990) and the Caregiving in the United States 2015 dataset, 1,156 caregivers were identified (including 278 young adults aged 18-39 years, 464 midlife adults aged 40-59 years, and 414 older adults aged 60-80 years). RES...
Source: International Journal of Aging and Human Development - Category: Geriatrics Tags: Int J Aging Hum Dev Source Type: research
In conclusion, FOXO4 possesses an anti-cancer glioma activity, which could be a novel target for future control of GBM.
Source: Life Sciences - Category: Biology Source Type: research
In this study, we chose Cytokeratin-pan, GFAP, and LCA as three immunohistochemical indicators. Intraoperative IHC was done by Novodiax ihcDirect technology combined with Leica Bond auto-staining. Compared with the manual method recommended for the reagents (Novodiax ihcDirect), the results show that auto-staining has better stability and high reproducibility in coloration, which has broad prospects for future application. PMID: 32055271 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
I am an Indian dentist with an MDS degree in periodontics from a reputed government college. Can I practice in the united states if I complete a 2-2.5 year degree completion/ advanced standing program from Canada?? Or should I try and apply for GPR/ AEGD in states? also, what are my chances of getting accepted in a GPR/AEGD program, considering that I am a foreign-trained dentist without US or Canada citizenship/permanent residency...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: International Dental Source Type: forums
Passengers and crew members quarantined off Japan were told by the American Embassy that a chartered flight would arrive on Sunday to take them back to the United States.
Source: NYT Health - Category: Consumer Health News Tags: Coronavirus (2019-nCoV) Quarantines China Hubei Province (China) Japan Beijing (China) Epidemics Source Type: news
This study intends to investigate the mechanisms of ubiqutin-specific protease 22 (USP22)/B cell-specific Moloney murine leukemia virus integration site 1 (BMI1) on the biological phenotypes of glioma stem cells (GSCs) under hypoxia.Main methodsWestern blot, Cell Counting Kit-8, colony formation and flow cytometry assays were preformed to evaluate cells biological behaviors. Luciferase assay was utilized to identify the associations among USP22, HIF-1α and BMI1.Key findingsSilencing USP22 reduced the stemness and proliferation of GSCs, and increased its apoptosis in response to hypoxia. Whilst, overexpression of BMI1...
Source: Life Sciences - Category: Biology Source Type: research
Motor vehicular transport (MVT) is a leading cause of injuries globally. Health care regionalization aims at improving patients ’ outcomes.
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Original Contributions Source Type: research
In conclusion, the approach of knowledge visualizations could inform coordinated multi-level decision making for improving food accessibility and reducing chronic diseases in locations defined by patterns of food access measures.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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