N ‐linked glycans in the variable domain of ACPA‐IgG predict the development of rheumatoid arthritis

ConclusionExtensive glycosylation of the ACPA ‐IgG V‐domain is present in a subset of predisposed FDRs of INA RA patients. The presence of this feature substantially increases the risk of RA development. Based on these findings, we propose that glycosylation of the ACPA‐IgG V‐domain represents a predictive marker for RA development in A CPA‐positive individuals and may serve to better target prevention measures.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatology - May 7, 2019 Category: Rheumatology Authors: Lise Hafkenscheid, Emma de Moel, Irene Smolik, Stacey Tanner, Xiaobo Meng, Bas C. Jansen, Albert Bondt, Manfred Wuhrer, Tom W. J. Huizinga, Rene E. M. Toes, Hani El ‐Gabalawy, Hans U. Scherer Tags: Full length Source Type: research