Lupus Affects Emotional, Mental Well - Being of Patients

Most patients report not having participated in a lupus clinical trial, despite interest
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Cardiology, Dermatology, Internal Medicine, Nephrology, Pulmonology, Rheumatology, Institutional, Source Type: news

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We describe a case of CA-ECM in Portugal in an adult patient with discoid lupus erythematosus under immunomodulatory therapy. A 73-year-old woman was admitted to the emergency department with fever and altered mental status over 48 hours. Cerebrospinal fluid analysis showed 185 leukocytes/μL, including 85% neutrophils, hypoglycorrhachia (less than 5 mg/dL) and elevated protein of 423 mg/dL with positive culture for Escherichia coli. She was treated with ceftriaxone. Imaging studies also demonstrated spondylodiscitis and arthritis. She responded well to antimicrobial therapy and completed the treatment as an outpatient.
Source: IDCases - Category: Infectious Diseases Source Type: research
Publication date: Available online 13 June 2019Source: International Journal for Parasitology: Parasites and WildlifeAuthor(s): Kevin D. Niedringhaus, Justin D. Brown, Kellyn M. Sweeley, Michael J. YabsleyAbstractThe “itch mite” or “mange mite”, Sarcoptes scabiei, causes scabies in humans and sarcoptic mange in domestic and free-ranging animals. This mite has a wide host range due to its ability to adapt to new hosts and has been spread across the globe presumably through human expansion. While disease caused by S. scabiei has been very well-studied in humans and domestic animals, there are still nu...
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
Increased concentrations of extracellular chromatin are observed in cancer, sepsis and inflammatory autoimmune diseases like systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). In SLE and RA, extracellular chromatin may behave as a danger-associated molecular pattern (DAMP). Polymorphonuclear neutrophils (PMN) are described as typical pro-inflammatory cells but possess also immunoregulatory properties. They are activated in SLE and RA but surprisingly remain moderately studied in these diseases, and especially the disease-associated stimuli triggering PMN activation are still not completely characterized. PMN ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
We report this case to raise the importance of clinical alertness for the rare but possibly underdiagnosed disease.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Verruciform Xanthoma (VX) is a benign condition occurring primarily in the oral cavity with some lesions also found on the genital mucosa or skin. VX occurs primarily in the fifth decade of life and shows a slight male predilection. This lesion generally presents as a papillary or rough-surfaced, painless, well-demarcated lesion, ranging from white, yellow-white, to orange in color. The etiology of VX is still largely unknown and definitive diagnosis is made based on histology. This lesion is thought to correlate with localized trauma or chronic inflammatory conditions such as lichen planus, lupus, epithelial dysplasia, pe...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: #103 Source Type: research
Purpose: To evaluate the infection incidence in breast cancer patients whether they have a major autoimmune disease or not.Methods: This retrospective cohort study compared the infection incidence of 174 breast cancer patients with an autoimmune disease, including Sjogren's Syndrome (SS), Rheumatoid Arthritis (RA), and Systemic Lupus Erythematosus (SLE), along with 4429 patients without an autoimmune disease, for the period 2000 to 2016. Six-hundred and ninety six, age-, stage-, and diagnosis era-matched patients without any autoimmune disease were analyzed to eliminate the effects of these confounding factors may have on ...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Authors: Xu W, Chen Z, Shen X, Pi C Abstract BACKGROUND: Realgar, an arsenic tetrasulfide compound, is a highly recognized traditional Chinese medicinal prescription that has been widely used to treat various diseases such as inflammatory diseases. However, there are still some problems in the clinical treatment of Realgar, such as large oral dose and high potential toxicity. OBJECTIVE: To evaluate effects of Realgar nanoparticles on lupus nephritis (LN) in vivo in MRL/lpr mice. METHODS: Ten-week mice were orally administered every day for eight consecutive weeks except the mice of normal model groups. The ...
Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
Nature Reviews Nephrology, Published online: 13 June 2019; doi:10.1038/s41581-019-0168-xIn a collaborative effort, researchers have identified unusual protein deposits of exostosin 1 and exostosin 2 in patients with PLA2R and THSD7A-negative membranous nephropathy, many of whom had systemic lupus erythematosus, lupus nephritis or other forms of autoimmunity. Although serum exostosin antibodies were not detected, the findings suggest that these proteins could define a distinct subtype of membranous nephropathy.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research
A 54-year-old woman presented with complaints of myalgias, fatigue, and progressive leg weakness of several weeks duration, followed by acute loss of vision in her left eye. Her medical history was notable for long-standing systemic lupus erythematosus (SLE) that was actively treated with prednisone, mycophenolate mofetil, and quinacrine.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: All Infections, Meningitis, Viral infections, Retina, Transverse myelitis Diagnostic and Treatment Challenges Source Type: research
This is a case report in which a patient with SLE had a brainstem variant of PRES, and MRI demonstrated atypical distribution of FLAIR hyperintensity in the thalami and the midbrain sparing the red nuclei bilaterally (Figure 1). This impressive lesion pattern may reveal the disease mechanisms of PRES in patients with SLE. AbstractThis is a case report in which a patient with SLE had a brainstem variant of PRES, and MRI demonstrated atypical distribution of FLAIR hyperintensity in the thalami and the midbrain sparing the red nuclei bilaterally (Figure 1). This impressive lesion pattern may reveal the disease mechanisms of P...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
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