Virus cocktail saves the life of dying girl amid hopes of breakthrough in fight against superbugs 

Isabelle Carnell-Holdaway, of Faversham, Kent, received a double lung transplant aged 17 to treat cystic fibrosis. But afterwards a drug-resistant superbug took hold of the teenager.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Scientists at the Howard Hughes Medical Institute have achieved a world’s first of beating a bacterial infection using an engineered virus. This was done in a 15-year-old girl with cystic fibrosis who had a severe case of Mycobacterium. The gir...
Source: Medgadget - Category: Medical Devices Authors: Tags: Genetics Medicine Public Health Surgery Source Type: blogs
We describe the use of a decontamination protocol that allowed for successful lung transplantation in a patient with cystic fibrosis with necrotizing pneumonia from highly antibiotic-resistant pathogens (Burkholderia and Psuedomonas species). This strategy may allow for successful lung transplantation in patients with cystic fibrosis with multidrug-resistant infections previously considered nontransplantable.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Body: Fosfomycin (F) has a unique mechanism of action against P.aeruginosa (PA) and may be active in multidrug-resistant (MDR) pathogens. F was not licensed in Europe since long time so the experience of F use is limited.Aim: To evaluate safety and efficacy of F IV for pulmonary exacerbations (PEs) in adults cystic fibrosis (CF).Methods: We analyzed the F use from Apr15 to Dec17 in combination with other IV antibiotics to treat 28 PEs in 15 CF patients (pts) in our centre.Results: 15 pts, 9 female, mean age 40.2 yrs (25-74), mean FEV1%pred 45 (25-70), PA chronic respiratory infection in 14, severe lung disease (FEV1
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
We describe the use of a decontamination protocol that allowed for successful lung transplantation in a cystic fibrosis patient with necrotizing pneumonia from highly antibiotic-resistant pathogens (Burkholderia and psuedomonas species). This strategy may allow for successful lung transplantation in cystic fibrosis patients with multi-drug resistant infections previously considered non-transplantable.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
We describe the use of a decontamination protocol that allowed for successful lung transplantation in a cystic fibrosis patient with necrotizing pneumonia from highly antibiotic-resistant pathogens (Burkholderia and psuedomonas species). This strategy may allow for successful lung transplantation in cystic fibrosis patients with multi-drug resistant infections previously considered non-transplantable. PMID: 30316849 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
ConclusionThere was a high correlation between pretransplant sinus cultures and posttransplant BAL cultures for PsA, MRSA, and Burkholderia sp. This suggests that the paranasal sinuses may act as a reservoir for allograft colonization in patients with cystic fibrosis. Further studies are needed to determine whether treatment of sinusitis affects allograft colonization and transplant outcomes.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusion: We propose that when CFA arrives at the airway, it rapidly adsorbs AMPs and creates negative complexes, thereby decreasing the functional amount of AMPs capable of killing pathogens. These results provide a novel translational insight into an early mechanism for how ambient PM increases the susceptibility of the airways to bacterial infection. https://doi.org/10.1289/EHP876 Received: 27 July 2016 Revised: 30 December 2016 Accepted: 19 January 2017 Published: 05 July 2017 Address correspondence to A. P. Comellas, 6312 Pappajohn Biomedical Discovery Building. Newton Road, Iowa City, Iowa, USA, 52242; Teleph...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
This article provides a review of immunosuppression regimens in the pediatric and adult CF post-LTx population, investigating drug dosing and monitoring, and medication combinations. Currently used immunosuppressive medications and related systemic adverse effects are reviewed. With limitations of data in the pediatric population, future research should address immunosuppression in these children to help guide pediatric drug management as a means to optimize clinical outcomes after LTx.
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
This article provides a review of immunosuppression regimens in the pediatric and adult CF post-LTx population, investigating drug dosing and monitoring, and medication combinations. Currently used immunosuppressive medications and related systemic adverse effects are reviewed. With limitations of data in the pediatric population, future research should address immunosuppression in these children to help guide pediatric drug management as a means to optimize clinical outcomes after LTx. PMID: 28547678 [PubMed - as supplied by publisher]
Source: Paediatric Drugs - Category: Pediatrics Authors: Tags: Paediatr Drugs Source Type: research
Post lung transplant infections for patients with cystic fibrosis can lead to sepsis and death in some cases due to antibiotic resistant bacteria that are colonizing the native lung pre transplant. Co-trimoxazole is the recommended treatment for infections with Stenotrophomas maltophilia but resistance to this agent or if patients are allergic other antimicrobials need identified. Conventional antimicrobial susceptibility testing methods are inadequate for determining the most effective antibiotic combinations against antibiotic resistant Gram negative bacteria.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
More News: Cystic Fibrosis | Girls | Health | Infectious Diseases | Lung Transplant | Superbugs | Transplant Surgery | Transplants