Hormone therapy may reduce the risk of miscarriage

A study published inThe New England Journal of Medicine has found that treating some women with progesterone during pregnancy can reduce the risk of miscarrying.BBC
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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CONCLUSIONS: Women with unexplained pregnancy loss demonstrated similar thrombin generation in the first trimester, regardless of the pregnancy outcome. CAT parameters failed to predict pregnancy outcome in women with recurrent unexplained pregnancy loss. Our results should be interpreted with caution due to the small number of participants. PMID: 31599511 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
CONCLUSION The therapeutic effect of combined treatment is better than clomifene citrate alone in the treatment of PCOS.RESUMO OBJETIVO Tendo em vista a alta incid ência de síndrome dos ovários policísticos (SOP) e os efeitos terapêuticos insatisfatórios da dimetildiguanida ou do citrato de clomifeno isoladamente, nosso estudo teve como objetivo investigar os efeitos terapêuticos da dimetildiguanida associada ao citrato de clomifeno no tratamento da SOP . MÉTODOS Um total de 79 pacientes com POCS e 35 mulheres saudáveis foram incluídos, e biópsias en...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
AbstractBackgroundA growing body of evidence suggests that microRNAs play fundamental regulatory roles in embryo implantation and maintenance of pregnancy. The aim of this study was to investigate the possible association between miR-146a C  >  G, miR-149 T >  C, miR-196a2 T >  C, and miR-499 A >  G polymorphisms and genetic susceptibility to recurrent pregnancy loss (RPL).Material and methodsOne hundred and twenty women with a history of two or more unexplained consecutive miscarriages and 90 ethnically matched healthy women with a history of at least two...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
The objective of our study was to generate and to compare mRNA profiles of NTDs with those of normal controls in the 2nd trimesters of pregnancy. Illumina microarray chips (beadarrays) were utilized to identify the altered mRNA transcripts in the organ samples recruited from Luliang Prefecture in Shanxi Province, China, which has the highest occurrence of NTDs in world. The beadarrays identified 101 un-regulated and 194 down-regulated mRNA transcripts in the NTDs compared with the controls in the spinal cord. A number of genes in the cholesterol biosynthesis pathway were down-regulated. In particular, SIRT2, a key regulato...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Publication date: Available online 8 October 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Michelle PetriAbstractAs SLE onset is often in young adulthood, pregnancy is common and is usually successful. Pregnancy, though, is considered high-risk due to a combination of maternal (lupus flare, diabetes, pre-eclampsia) and fetal (miscarriage, intrauterine fetal demise, preterm birth, intrauterine growth restriction, congenital heart block) risks.Pregnancy should be planned for a time of good control of SLE (on allowable medications). The antimalarial hydroxychloroquine should be continu...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
This month, Kayla and Lance Edwards welcomed their daughter Indy Pearl Edwards into the world, and became the fourth couple to have a child through the uterus transplant program at Baylor Scott &White Health’s Baylor University Medical Center. The couple would have had a great love story even without those extraordinary circumstances. They attended elementary school together in Vancouver, Wash., lost touch, and then reconnected through social media more than a decade later. After months of chatting through the game “Words with Friends,” they finally went on a date in January 2013 and got engaged about...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized embargoed study medicine Source Type: news
Sukhyanti Kerai, Kirti Nath Saxena, Bharti WadhwaIndian Journal of Anaesthesia 2019 63(10):786-790 Surgery in a patient with unrecognised pregnancy has serious ethical and medicolegal implications. There are no guidelines in India for preoperative pregnancy testing (POPT) in surgical patients. This review was undertaken to ascertain utility of routine POPT and whether any specific indication for POPT could be suggested. We performed a literature search to identify publications pertaining to POPT in surgical patients. Searches included PubMed, Google Scholar and internet search for national guidelines. Studies pertaining t...
Source: Indian Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
CONCLUSION:  These results indicate that chronic hypercoagulability and impaired clot contraction constitute a premorbid status in patients with pregnancy loss. The data confirm a significant pathogenic role of hemostatic disorders in pregnancy loss and suggest the predictive value of thrombodynamics and blood clot contraction assays in evaluating the risk of pregnancy loss. PMID: 31587245 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
Conclusion: A combination of patient-centred care focusing on safe, effective contraception and medication targeting remission state, constant counselling, consistent information, and a pregnancy managed jointly by an obstetrics and rheumatology team could achieve optimum results. PMID: 31583923 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
This report on the progress toward rubella and CRS control and elimination updates the 2017 report (3), summarizing global progress toward the control and elimination of rubella and CRS from 2000 (the initiation of accelerated measles control activities) and 2012 (the initiation of accelerated rubella control activities) to 2018 (the most recent data) using WHO immunization and surveillance data. Among WHO Member States,* the number with RCV in their immunization schedules has increased from 99 (52% of 191) in 2000 to 168 (87% of 194) in 2018†; 69% of the world's infants were vaccinated against rubella in 2018. Rube...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
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