The immune microenvironment in hormone receptor-positive breast cancer before and after preoperative chemotherapy.

CONCLUSIONS: The immune microenvironment of HR+/HER2-tumors differs according to tumor biology. This cohort of paired pre-/post-chemotherapy samples suggests a critical role for immunosuppressive macrophage expansion in residual disease. The role of macrophages in chemo-resistance should be explored and further evaluation of macrophage-targeting therapy is warranted.
PMID: 31061067 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - May 5, 2019 Category: Cancer & Oncology Authors: Waks AG, Stover DG, Guerriero JL, Dillon DA, Barry WT, Gjini E, Hartl CA, Lo WT, Savoie J, Brock J, Wesolowski R, Li Z, Damicis A, Philips AV, Wu Y, Yang F, Sullivan A, Danaher P, Brauer HA, Osmani W, Lipschitz M, Hoadley KA, Goldberg MS, Perou CM, Rodig Tags: Clin Cancer Res Source Type: research