Intraoperative Soft Tissue Balance/Kinematics and Clinical Evaluation of Modified Kinematically versus Mechanically Aligned Total Knee Arthroplasty

J Knee Surg DOI: 10.1055/s-0039-1688504Recently, kinematically aligned total knee arthroplasty has been found to achieve better clinical outcomes than mechanically aligned TKA. Despite the good clinical outcomes that are reported at short- to mid-term follow-up, intraoperative variables that are associated with a better outcome have not been measured. Therefore, this study was conducted to compare intraoperative kinematics/soft tissue balance and the clinical outcomes of patients who underwent modified kinematically (restricted tibial cut) or mechanically aligned total knee arthroplasty. Sixty cruciate-retaining total knee arthroplasties (30 modified kinematically [3-degree varus and 7-degree posterior slope in tibial cut] and 30 mechanically aligned) were performed in patients with varus-type osteoarthritis using a navigation system. Intraoperative kinematics assessed by the navigation system and soft tissue balance assessed by an offset-type tensor were compared between the groups. One year postoperatively, the range of motion and 2011 Knee Society scores were compared between the groups. Kinematic assessment exhibited that tibial internal rotation during flexion was significantly maintained in the kinematic compared with the mechanical group (p 
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research

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ConclusionDespite minimal group-level effects of chronic diet-induced obesity and voluntary wheel running on knee OA pathology under the current test durations, diet and exercise substantially altered the relationships among systemic and local variables associated with early-stage knee OA. These results suggest that distinct pre-OA phenotypes may exist prior to the development of disease.Graphical Abstract
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
ConclusionAmong veterans undergoing primary THA at a VA hospital, patients undergoing DAA THA had better perioperative outcomes than patients treated with the posterior approach despite similar demographics, American Society of Anesthesiologists score, and the DAA learning curve.
Source: Journal of Arthroscopy and Joint Surgery - Category: Orthopaedics Source Type: research
Conclusion10-week-old C57/BL6 male mice were induced to undergo OA by destabilization of medical meniscus (DMM) or SHAM surgery. 3 weeks post-surgery, mice were injected intra-articularly with saline or ferumoxytol-labeled murine MSCs (50 × 103 MSCs/mouse) to yield the following groups (n=5/group): i) DMM+MSC with ferumoxytol; ii) DMM+MSC without ferumoxytol iii) DMM+Saline; iv) SHAM+MSC; and v) SHAM+Saline. MRIs of mice were taken at 1, 3 days and 1, 2, or 4 weeks after injection. At 4 weeks post-injection, mice were scored for i) OARSI to determine cartilage damage and synovitis and ii) immunohistochemical chan...
Source: Cytotherapy - Category: Cytology Source Type: research
Conclusion MethodologyThere were 4 clinical trials approved at the National University Malaysia in collaboration with Cytopeutics (Cyberjaya, Malaysia) which provided the mesenchymal stromal cells (Cyto-MSC) for treatment of acute stroke, heart failure, diabetes with critical limb ischemia and severe deforming osteoarthritis. All patients received 65-130 × 106 Cyto-MSC intravenously. Severity of chronic kidney disease is based on baseline estimated glomerular filtration rate (eGFR) and serum creatinine which are markers of renal dysfunction. These and other blood tests including fasting blood sugar (FBS) and Hba1...
Source: Cytotherapy - Category: Cytology Source Type: research
Conclusion MethodThis is a single-arm, open-label, compassionate study at the Universiti Kebangsaan Malaysia Medical Centre (UKKMC) with 12 months follow-up period. Subjects with knee articular cartilage defect ICRS 3 diagnosed via diagnostic arthroscopy were treated with allogeneic UC-MSCs (Chondrocell-Ex, Cytopeutics, Malaysia) and assessed in five subsequent visits. During the visits, assessment was done following Visual Analog Score (VAS), International Knee Documentation Committee (IKDC), Tegner Activity Score (TAS), and Knee injury and Osteoarthritis Outcome Score (KOOS) scoring. At the end of the study, subjects und...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionHere we show that in twelve clinical cases, the cartilage was observed successfully regenerating and covering the defect region in knees after the intra-articular injection with adipose-derived mesenchymal stem cells (MSCs), and the treatment highly improves the symptoms of osteoarthritis. Basically, the adipose-derived MSCs from the patients are cultured and expanded to a specific amount with the optimized stem cell culture medium, the HELENE MEDIUM. After that, the cultured MSCs are directly injected into the injured knee joints of patients. The cartilage has gradually regenerated and been monitored by MRI phot...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionCulture of Wharton Jelly MSC at 1 litre with Solohill microcarriers showed 25% improved cell densities of the Bach impeller over the axial flow and paddle impellers: 4 × 10e5 cells/ml vs. 3 × 10e5 cells/ml. This was primarily due to extensive clumping of cell-microcarrier aggregates seen in the conventional impellers from day 3 onwards; whereas the laminar flow prevented aggregation up to the final day of harvesting.Significantly, when MSC were cultured on Cytodex microcarriers at 1 litre, cell yields increased dramatically to 15 × 10e5 cells/ml; viability and identity were equivalen...
Source: Cytotherapy - Category: Cytology Source Type: research
Conditions:   Knee Osteoarthritis;   Cartilage Injury Intervention:   Device: shock wave device Sponsor:   Peking University Third Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionThis study has evidenced that there is a large percentage of sub-threshold population. i.e. K-L grade 1 which is considered as border-line or doubt-full as far as OA diagnosis. Awareness of OA should be initiated at community level, which is needed for prevention of OA at early age.
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Contributors : Kathleen Cheung ; David Young ; Matt BarterSeries Type : Methylation profiling by genome tiling arrayOrganism :Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic mechanisms including DNA methylation. Methylation changes may also play a key role in lineage specification during stem cell differentiation. To further our understanding of epigenetic regulation in chondrocytes we characterised DNA methylation changes during chondrogenesis of mesenchymal stem cells (MSCs) by Infinium 450K methylation array. Significant DNA hypomethylation was identified during chondrogenesi...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Source Type: research
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