Global Health: A New Ebola Vaccine Strategy in Africa: Smaller Doses

As violence makes it harder to reach stricken villages in Congo, experts plan to stretch supplies and to give the vaccine to everyone, not just contacts of victims.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Ebola Virus Vaccination and Immunization Congo, Democratic Republic of (Congo-Kinshasa) Epidemics World Health Organization Johnson & Merck Company Inc Source Type: news

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Even with more than 1,400 dead, the W.H.O. says the risk of the disease spreading beyond the region remains low and declaring an emergency could have backfired.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Epidemics Ebola Virus Vaccination and Immunization World Health Organization Centers for Disease Control and Prevention United Nations Children ' s Fund Congo, Democratic Republic of (Congo-Kinshasa) Africa Uganda Tedros Adhanom Gheb Source Type: news
(KASINDI, Congo) — A 5-year-old boy vomiting blood became the first cross-border victim of Ebola in the current outbreak on Wednesday, while two more people in Uganda tested positive for the highly contagious disease that has killed nearly 1,400 in Congo. The boy, part of a Congolese family who crossed into Uganda earlier in the week, died overnight, the World Health Organization said. Ugandan authorities said the two new cases are his 3-year-old brother and 50-year-old grandmother, who have been isolated at a hospital near the border. Uganda now has three confirmed Ebola cases. Authorities tried to determine how the...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Disease ebola Infectious Disease onetime Uganda Source Type: news
Congo's Ebola epidemic is expected to continue spreading though the country's east, where it has killed 1,000 since August and sparked mistrust and frequent attacks on medical centers, the World Health Organization (WHO) said on Friday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Pregnant women &vaccines against emerging epidemic threats: Ethics guidance for preparedness, research, and response. Vaccine. 2019 May 03;: Authors: Krubiner CB, Faden RR, Karron RA, Little MO, Lyerly AD, Abramson JS, Beigi RH, Cravioto AR, Durbin AP, Gellin BG, Gupta SB, Kaslow DC, Kochhar S, Luna F, Saenz C, Sheffield JS, Tindana PO, PREVENT Working Group Abstract Zika virus, influenza, and Ebola have called attention to the ways in which infectious disease outbreaks can severely - and at times uniquely - affect the health interests of pregnant women and their offspring. These examples also hig...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Source: World Health Organization (WHO). Published: 4/12/2019. This four-page report provides information about preliminary analysis that was completed with the aim to better understand whether or not the rVSV-ZEBOV-GP candidate vaccine is effective and is contributing to prevent cases of Ebola virus disease when delivered using the ring vaccination strategy. This experimental Ebola vaccine is being used to try to contain the outbreak in the Democratic Republic of the Congo, and is protective 97.5 percent of the time. These early results confirm previous observations of high efficacy of rVSV-ZEBOV-GP Ebola vaccine against disease. (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
In this study, we evaluated ATA as a potential antiviral drug against ZIKV replication. The antiviral activity of ATA against ZIKV replication in vitro showed median inhibitory concentrations (IC50) of 13.87 ± 1.09 μM and 33.33 ± 1.13 μM in Vero and A549 cells, respectively; without showing any cytotoxic effect in both cell lines (median cytotoxic concentration (CC50)> 1,000 μM). Moreover, ATA protected both cell types from ZIKV-induced cytopathic effect (CPE) and apoptosis in a time- and concentration-dependent manner. In addition, pre-treatment of Vero cells with ATA for up to 72 h also resulted...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Jeffrey G. Shaffer1*, Frances J. Mather1, Mamadou Wele2, Jian Li1, Cheick Oumar Tangara2, Yaya Kassogue2, Sudesh K. Srivastav1, Oumar Thiero2, Mahamadou Diakite2, Modibo Sangare2, Djeneba Dabitao2, Mahamoudou Toure2, Abdoulaye A. Djimde2, Sekou Traore2, Brehima Diakite2, Mamadou B. Coulibaly2, Yaozhong Liu1, Michelle Lacey3, John J. Lefante1, Ousmane Koita2, John S. Schieffelin4, Donald J. Krogstad1 and Seydou O. Doumbia2 1Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States 2Faculty of Medicine and Odontostomatology, Un...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs
By MARC M. BEUTTLER, MD Every year at this time, you hear warnings that flu season has arrived. New data from the CDC indicates the season is far from over. So, you are urged by health authorities to get a flu shot. What you may not realize is how the flu can affect the hospitals you and your loved ones rely on for care.   In January, the large urban hospital where I am an intern faced the worst flu outbreak it has ever seen. Nearly 100 staff members tested positive for the flu. Residents assigned to back-up coverage were called to work daily to supplement the dwindling ranks of the sick. Every hospital vis...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Hospitals Medical Practice Marc Beuttler Vaccination Source Type: blogs
Abstract Vaccination remains the most successful and effective mechanism of pathogen control. However, their development and deployment in epidemic settings have been limited, and the 2015 Ebola outbreak in West Africa identified several bottlenecks linked to a lack of investment in pathogen research, infrastructure or regulation. Shortly after this outbreak, the UK Government established the UK Vaccine Network to ensure the UK is better prepared to respond to pathogens outbreaks of epidemic potential. As part of their work, the network commissioned the creation of a Vaccine Development Tool (http://www.vaccinedev...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
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