Reactive Perforating Collagenosis in End-Stage Renal Disease: Not All that Itches Is Uremic Pruritis!

A 51-year-old woman with a history of end-stage renal disease, hypertension, and diabetes mellitus type 2 who had been on hemodialysis for 4 years presented with an extremely itchy diffuse skin rash that she initially noticed 2 weeks prior to presentation. The itching was significant enough to impair her quality of life, and she had tried applying various over-the-counter anti-itch creams without much relief. Examination of the skin was notable for diffusely scattered blackish hyperpigmented, dome-shaped, umbilicated papules, some coalescing into plaques on the trunk and extremities.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research

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High blood pressure: A common diagnosis, that shows hardly any symptoms, but can be deadly. Hardened arteries and blood forced too hard against artery walls can lead to a heart attack or stroke. Fortunately, there are lifestyle improvements that can lower blood pressure and potentially save your life.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Abbott Laboratories has been wildly successful with its FreeStyle Libre continuous glucose monitor (CGM) since winning FDA approval in 2017, but it seems some investors and patients may be getting restless as the U.S. market waits for the second-generation of the blockbuster technology. We first noted some signs of impatience for Libre 2 in our coverage of Abbott's third-quarter earnings call in October. One reader commented on that article that "I don’t particularly care about investors becoming impatient, as a Freestyle Libre user I am growing impatie...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
ConclusionLig exerts renoprotective functions in an animal model of DN mediated by antioxidant action, inhibition of apoptosis, anti-inflammatory action, reduction of renal fibrosis, reduction of the proliferation of mesangial cells, inhibition of endotheliosis, inhibition of atherosclerosis and promotion of renal autophagy. The positive conclusion should be treated cautiously because of various methodological flaws. Further studies are recommended according to ARRIVE guidelines. The method of modeling with high-dose STZ should be avoided and improved STZ modeling schemes are recommended. Considering the large dosage range...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
TYPE 2 diabetes is a chronic condition that may require you to forgo your favourite treats to stave off the risks posed by rising blood sugar levels. Certain foods may seem healthy on the surface but contain hidden risks that can send blood sugar soaring, including a popular breakfast item.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 22 January 2020Source: Food BioscienceAuthor(s): Chengcheng Zhao, Jing Miao, Xia Li, Xuetao Chen, Xinhui Mao, Ying Wang, Xiangmei Hua, Wenyuan GaoAbstractChaenomeles speciosa (CS) and Crataegus pinnatifida (CP) are two common Chinese fruits with health benefits. The effect of in vitro digestion on the chemical composition, antioxidant activity and α-glucosidase inhibitory activity of these two fruits, as well as the accessibilities of their active compounds were studied. The inhibitory effects on starch digestion of CS, CP and the 5 identified compounds also were measured. It was ob...
Source: Food Bioscience - Category: Food Science Source Type: research
Publication date: Available online 22 January 2020Source: Journal of Microbiological MethodsAuthor(s): Rakan H. Yousef, Othman A.S. Baothman, Wesam H. Abdulaal, Mohamed K. Abo-Golayel, Anass Darwish, Said S. Moselhy, Youssri M. Ahmed, Khalid Rehman HakeemAbstractThe major functions of Exopolysaccharide (EPS) are, preventing bacterial cells from desiccating and biofilm production to increase the colonization of bacterial cells. In the current study, a bacterial strain was isolated to produce EPS. Phylogenetic analysis of the isolated strain indicated it was related to Bacillus subtilis. The bacterium showed the ability to p...
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
This article is part of a Special Issue entitled: GSK-3 and related kinases in cancer, neurological and other disorders edited by James McCubrey, Agnieszka Gizak and Dariusz Rakus.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
This study was aimed to evaluate association of vitamin D receptor gene polymorphisms with susceptibility to T2DM.Subjects and methods: One hundred T2DM Saudi male patients were included in this study and one hundred healthy Saudi men were used as control. For each individual, fasting blood glucose, cholesterol, HDL-C, LDL-C, HbA1c, insulin and 25-(OH) vitamin D were measured. In addition,Apal, BsmI and TaqI genotypes were performed for each subject. Data was analyzed by SPSS version 16, using Spearman's rho and ANOVA tests.Results: There was significant inverse correlation between 25-(OH) vitamin D level and T2DM (p
Source: African Health Sciences - Category: African Health Source Type: research
Conclusion: Age, WHR, FPG, and SBP were significantly associated with differences in glycemic control. The elderly and FPG outside tight control showed significantly increased odds of poor glycemic control status.Keywords: Type 2 Diabetes Mellitus; glycemic control status; A1C; Elderly; Fasting plasma glucose; glycemic control predictors.
Source: African Health Sciences - Category: African Health Source Type: research
Conclusion The elucidation of the function of circRNAs is an emerging field of science with a tremendous potential after previously being dismissed as RNA artifacts. They are ubiquitously expressed and thousands of members have already been identified. This fact only expands their potential to possibly enhance our knowledge to understand the difference between health and disease. Owing to their structure stability and their presence in exosomes circRNAs may also exert their function in an autocrine, paracrine and possible endocrine fashion. In addition, the fact that circRNAs are widely distributed in the cellular compart...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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