A tribute to Cochrane consumer, Tony Joy

Cochrane is a global independent network of researchers, professionals, and people interested in health, including healthcare consumers. Cochrane's healthcare consumers are made up from a wide range of people, including patients (or people with personal experience of a healthcare condition), health and social care service users, caregivers and family members. Also included are people who represent or are advocates for patients and carers. What unites them all is their search for high quality, unbiased information about health conditions and treatments.Professor Clive E Adams, Co-cordinating Editor ofCochrane Schizophrenia, shares memories of Tony Joy and his valuable contributions made to Cochrane Reviews as a consumer.Maybe it was 1993. I am not sure. Iain Chalmers sent along this quizzical, unremittingly dogged, intelligent, kind and fun UK Midlands businessman. He had an interest in schizophrenia and wanted to help. We had recently published a blockbuster review (new vs old drug) and were rather pleased with the product – smug, even. Tony lay/peer reviewed it and went straight to the key outcome – a 20% shift on the foremost scale in schizophrenia. He asked “what does that mean?”, “can you put it into words?”. We did not know or how. Our bubble burst. It was quite some time later, still troubled by our deficiencies, that I was able to meet up with the senior US professor linked to that scale and asked her Tony’s question. She immed...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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Suicide is an important public health problem. The most frequent psychiatric illnesses associated with suicide or severe suicide attempt are mood and psychotic disorders. The purpose of this paper is to provide an educational overview of suicidal behavior ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
BACKGROUND: It is still unknown whether many well-identified risk factors of suicide could be applied to the elderly Chinese patients with schizophrenia. METHODS: 1-month suicidal ideation and lifetime suicide attempts together with their sociodemo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Molecular Psychiatry, Published online: 15 July 2019; doi:10.1038/s41380-019-0456-7Correction: Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Source: Molecular Psychiatry - Category: Psychiatry Authors: Source Type: research
Authors: Cocoman AM, Gallagher D Abstract Individuals who are treated with antipsychotic medications are at risk of developing metabolic syndrome (MetS). The comorbidity of a severe mental illness (SMI) and a physical illness has a major impact on the quality of life of these individuals. We conducted a retrospective chart review (RCR) of 214 individuals with a diagnosis of schizophrenia who had been receiving antipsychotic medications for at least 6 months, in five clinical settings in an Irish community mental health service. The aim was to determine the presence of MetS to assist in improving screening pr...
Source: Issues in Mental Health Nursing - Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
Publication date: Available online 13 July 2019Source: Brain, Behavior, and ImmunityAuthor(s): Seyma Katrinli, Adriana Lori, Varun Kilaru, Sierra Carter, Abigail Powers, Charles F. Gillespie, Aliza P. Wingo, Vasiliki Michopoulos, Tanja Jovanovic, Kerry J. Ressler, Alicia K. SmithAbstractBackgroundImmune dysregulation has been widely observed in those with posttraumatic stress disorder (PTSD). An individual’s immune response is shaped, in part, by the highly polymorphic Human Leukocyte Antigen (HLA) locus that is associated with major psychiatric disorders such as schizophrenia, major depression and bipolar disorder. ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: Available online 12 July 2019Source: Neuroscience ResearchAuthor(s): A. Sánchez-González, I. Oliveras, C. Río-Álamos, MA. Piludu, C. Gerbolés, C. Tapias-Espinosa, A. Tobeña, S. Aznar, A. Fernández-TeruelABSTRACTSocial isolation rearing of rodents is an environmental manipulation known to induce or potentiate psychotic-like symptoms and attentional and cognitive impairments relevant for schizophrenia. When subjected to a 28-week isolation rearing treatment, the Roman high-avoidance (RHA-I) rats display the common behavioral social isolation syndrome, with pr...
Source: Neuroscience Research - Category: Neuroscience Source Type: research
Publication date: 13–19 July 2019Source: The Lancet, Volume 394, Issue 10193Author(s): Shahzain Hasan, Munsif Adil
Source: The Lancet - Category: General Medicine Source Type: research
Conclusions for the primary outcome did not substantially change after adjusting for possible effect moderators or in sensitivity analyses (eg, when excluding placebo-controlled studies). The confidence in evidence was often low or very low.InterpretationThere are some efficacy differences between antipsychotics, but most of them are gradual rather than discrete. Differences in side-effects are more marked. These findings will aid clinicians in balancing risks versus benefits of those drugs available in their countries. They should consider the importance of each outcome, the patients' medical problems, and preferences.Fun...
Source: The Lancet - Category: General Medicine Source Type: research
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Source: Scandinavian Journal of Primary Health Care - Category: Primary Care Authors: Source Type: research
AbstractMethylenetetrahydrofolate reductase (MTHFR) polymorphism may increase the risk of schizophrenia in adults and aggravate related symptoms, while it is unknown whether similar risk applies in children with schizophrenia. While average onset age of schizophrenia is between the ages of 15 and 25, there are no studies on the relationship betweenMTHFR polymorphism and childhood-onset schizophrenia (COS). Here, we aimed to explore the risk ofMTHFR polymorphism in children and examine the effects ofMTHFR polymorphism on disease onset and clinical features in the COS patients. Pediatric patients with schizophrenia (n&thinsp...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
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