Biomarker-Guided Anti-inflammatory Therapies

Novel therapy development in psychiatry is at an impasse, with a significant lull since the 1980s and 1990s when most of the monoamine-targeted therapies that form the foundation of modern practice were first launched. The monoaminergic targets of such therapies have failed to deliver novel treatments. Instead, some of the most promising novel therapies have arisen from the twin biomarker findings of increased inflammation and oxidative stress across the major psychiatric disorders, including depression, schizophrenia, and bipolar disorder. Research on inflammation and oxidative stress has led to the identification of promising repurposed therapeutic options, which include celecoxib, minocycline,N-acetylcysteine, statins, aspirin, and infliximab. The logical next step, and a long-term goal of precision psychiatry, is to use hypothesized biomarkers to guide treatment choices and enhance therapy responses. Theoretically, people stratified to have higher or lower levels of the biomarker of interest should be more likely to respond to therapy with an agent that engages that target, which is a premise of the Research Domain Criteria philosophy.
Source: JAMA Psychiatry - Category: Psychiatry Source Type: research

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Authors: Theodoropoulou S, Gialouris AG Abstract Brain is an organ with the highest lipid concentration in the body. Cellular membrane lipids can affect both the positioning and the functioning of membrane proteins, thus regulating several cell actions. Changes in the lipid composition of cell membrane can modulate the microenvironment and consequently the function of its proteins, e.g. neurotransmission. Some of the first studies on the subject have shown a negative correlation between serum cholesterol levels and depression, suicidality and behavioral disorders. Several studies -but not all- have found decreased ...
Source: Psychiatriki - Category: Psychiatry Tags: Psychiatriki Source Type: research
This study presents findings from a large sample with extensive clinical phenotyping—allowing us to examine the relationships of insulin resistance with a number of key psychopathological, cognitive, and functioning measures, using multivariate methods to assess the relative contributions of different factors to metabolic abnormalities. PwS often have many risk factors for metabolic abnormalities: lifestyle habits, medications, and underlying biological mechanisms including inflammation and oxidative stress. Treatment and prevention of metabolic abnormalities in PwS can be particularly challenging due to these multip...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study shows that some genetic changes linked to cancer are present in surprisingly large numbers of normal cells. We still have a long way to go to fully understand the implications of these new findings, but as cancer researchers, we can't underestimate the importance of studying healthy tissue." Early Onset of Menopause Correlates with Shorter Life Expectancy https://www.fightaging.org/archives/2018/10/early-onset-of-menopause-correlates-with-shorter-life-expectancy/ Aging is a phenomenon affecting all organs and systems throughout the body, driven by rising levels of molecular damage. The v...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion The relationships between the potency of 5-HT2C blockade and hypertriglyceridemia and the potency of M3 blockade and glucose intolerance were shown in clinical setting. Receptor-binging profiles might be useful to estimate metabolic effect of antipsychotics-treatment. References Meyer JM, Davis VG, Goff DC, et al. Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: prospective data from phase 1. Schizophr Res. 2008;101: 273–286. Salvi V, Mencacci C, Barone-Adesi F. H1-histamine receptor affinity predicts weight gain with antidepressants. Eur Neuropsychoph...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Letters to the Editor Asenaprine clozapine olanzapine schizophrenia Source Type: research
Authors: Gohar SM, Dieset I, Steen NE, Mørch RH, Iversen TS, Steen VM, Andreassen OA, Melle I Abstract Although the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. We here examined the association between lipid levels and depressive symptomatology in patients with psychotic disorders, in addition to their possible inflammatory associations. Participants (n = 652) with the following distribution: schizophrenia, schizophreniform ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
AbstractAlthough the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. We here examined the association between lipid levels and depressive symptomatology in patients with psychotic disorders, in addition to their possible inflammatory associations. Participants (n = 652) with the following distribution: schizophrenia, schizophreniform and schizoaffective disorder (schizophrenia group,n = 344); bipolar I, II, NOS, and psychosis NO...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
I’m a little dumb-founded whenever I run across a prescribing trend that goes against all of the available empirical evidence for common sense use of a medication. Nowhere is this more evident than with the prescription of atypical antipsychotic medications. It wouldn’t be too far a stretch to suggest that such prescriptions have become like Prozac prescriptions in the 1990s, the latest medication fad. But atypical antipsychotics, like Seroquel (quetiapine fumarate), are far more complex with far more problematic side effects than drugs like Prozac, and should only be prescribed for on-label use. The Washingto...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic General Medications Policy and Advocacy Adverse Effects Atypical Antipsychotic Bipolar Disorder Insomnia movement disorder Seroquel side effects Weight Gain Source Type: blogs
DiscussionThe findings of this study highlight the importance of understanding the interaction between inflammatory markers and lipid, and their relation to clinical profile especially depression in psychotic disorders
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research
AbstractTo assess the feasibility, acceptability, and preliminary effectiveness of a peer-delivered and technology supported integrated medical and psychiatric self-management intervention for older adults with serious mental illness. Ten older adults with serious mental illness (i.e., schizophrenia, schizoaffective disorder, bipolar disorder, or major depressive disorder) and medical comorbidity (i.e., cardiovascular disease, obesity, diabetes, chronic obstructive pulmonary disease, hypertension, and/or high cholesterol) aged 60  years and older received the PeerTECH intervention in their homes. Three certified peer ...
Source: Psychiatric Quarterly - Category: Psychiatry Source Type: research
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