Hidradenitis suppurativa and risk of suicide - systematic review and meta-analysis.

Hidradenitis suppurativa and risk of suicide - systematic review and meta-analysis. J Dermatolog Treat. 2019 May 07;:1-8 Authors: Phan K, Loya A, Ramachandran V, Smith SD Abstract The painful and chronic nature of hidradenitis suppurativa (HS) and associated stigma leads to detrimental impact on patients' quality of life. There is increasing evidence that HS is associated with various psychiatric comorbidities including depression, anxiety disorders and psychoses. However, few studies have investigated the relationship between HS and suicide risk. We performed a systematic review and meta-analysis to determine whether HS patients are at elevated risk of suicide compared to controls. 1128 studies were identified from the systematic literature search. After removal of duplicates, title and abstract screening, and application of inclusion and exclusion criteria, there were 4 articles comprised of 86,151 HS cases compared with 114,579,054 controls. From unadjusted meta-analysis, we found an association between HS and suicide (OR 2.24, 95% CI 1.35-3.71, P = 0.002) (Figure 1). There was heterogeneity noted (I2=98%). Meta-analysis with adjusted effect sizes was also performed, and we found an association between HS and suicides compared to controls (OR 2.11, 95% CI 1.43-3.12, P = 0.0002, I2=91%). Our systematic review and meta-analysis findings demonstrate the profound effect HS can have on mental health. Clinicians should be aware ...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research