Potential Roles of Siglecs in the Regulation of Allo-Immune Reaction.

Potential Roles of Siglecs in the Regulation of Allo-Immune Reaction. Curr Protein Pept Sci. 2019 May 06;: Authors: Cai S, Zhao J, Ueno T, Chandraker A Abstract Siglecs are mammalian sialic acid (Sia) recognizing immuno-globulin-like receptors ex- pressed across the major leukocyte lineages, and function to recognize ubiquitous Sia epitopes on the cell surface. Many Siglecs are inhibitory receptors expressed on innate immune cells, they also have a role in maintaining B cell tolerance as well as modulating the activation of conventional and plasmo-cytic dendritic cells. Through these and other roles they contribute directly and indirectly to the regulation of T cell function. Siglecs have been identified to play key roles in several forms of blood cancers, autoimmune and infection deceases. So far as we know, there's no Siglecs related research works on solid organ transplantation. In this review, we describe our understanding of the potential roles of Siglecs in the regulation of immune cell function, which may be crosslinked to allo-rejection and ischemia-reperfusion injury. PMID: 31060487 [PubMed - as supplied by publisher]
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Tags: Curr Protein Pept Sci Source Type: research