RCT: Immunosuppression for progressive membranous nephropathy

Source: Lancet Area: News Membranous nephropathy is the most common cause of primary nephrotic syndrome in adults and leads to end-stage renal disease in more than 20% of patients. Although immunosuppressive therapy benefits some patients, trial evidence for the subset of patients with declining renal function is not available. The UK Renal Association Clinical Trials Committee's glomerulonephritis subgroup aimed to assess whether immunosuppression preserves renal function in patients with idiopathic membranous nephropathy with declining renal function.   This trial was conducted in 37 renal units across the UK and recruited 108 patients (aged 18 to 75 years) with biopsy-proven idiopathic membranous nephropathy, a plasma creatinine concentration < 300 micromol/L, and at least a 20% decline in excretory renal function measured in the 2 years before study entry, based on at least three measurements over a period of ?3 months. Patients were randomised (1:1:1) to receive:   ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news