Albizia julibrissin Ameliorates Memory Loss Induced by Insomnia in Drosophila.

Albizia julibrissin Ameliorates Memory Loss Induced by Insomnia in Drosophila. Evid Based Complement Alternat Med. 2019;2019:7395962 Authors: Chang JS, Liu HP, Cheng J, Chen CJ, Hwang SL, Tseng CC, Hsu LF, Lin WY Abstract In clinical practice in Taiwan, Albizia julibrissin is the most prescribed Chinese herbal medicine for insomnia. Short-term insomnia and hypnotic use both attenuate cognitive functions, especially learning memory. In previous studies, A. julibrissin exhibits sedative activity, antidepressant-like effects, and protection of learning and memory against amnesia. However, whether A. julibrissin ameliorates memory loss caused by short-term sleep deprivation is not clear. We utilized the sleep-deprived Drosophila model and olfactory associative learning-memory assay to test the effects of A. julibrissin on sleep-deprivation induced memory loss. We found that A. julibrissin ameliorated 3-hour memory but not 1-hour memory or instant learning. The findings might be applied to an anticipated short-term sleep disturbance. PMID: 31057652 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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Insomnia is a prevalent disorder that affects over one-third of the U.S. population to varying degrees and is highly disruptive towards quality of life. Pharmacological treatments for insomnia include benzodiazepines (BZs) and the non-BZ ‘Z-drugs’ (zolpidem, zaleplon, eszopiclone, zopiclone), which are amongst the most widely prescribed medications. Yet, these agents can produce adverse effects such as tolerance to the hypnotic effect, rebound insomnia, next-day residual drowsiness, as well as amnesia and complex behaviours such as sleep-walking, sleep-eating and sleep-driving. Quazepam, one of the five BZ appr...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Review Articles Source Type: research
In conclusion, these results indicated that loganin produced beneficial sedative and hypnotic activity, which might be mainly mediated by modification of the serotonergic system and GABAergic neurons. Introduction Insomnia is referred to as continuous difficulty in initiating or maintaining sleep, which can induce extreme medical and psychiatric disorders (Cao et al., 2016). It was reported that 27 percent of people in the world suffering from insomnia (Doghramji, 2006), and approximately 3–10 percent of people would frequently depend on hypnotics to overcome insomnia by 2050 (Chu et al., 2007). Clinically, b...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsDifferent patterns of sleep disturbances are observed in HD patients: insomnia, difficulties in falling asleep, frequent nocturnal awakenings, and excessive daytime sleepiness are the most common sleep problems reported by patients with HD. In several HD studies, specific changes in sleep architecture and in circadian melatonin secretion were identified in laboratory testing.Sleep disorders in HD have diverse and complex determinants, the most significant of which includes damage to brain areas that are responsible for the proper sleep pattern and circadian rhythm regulation. Sleep and circadian rhythm disorders...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In conclusion, our results suggest that PF lead high hippocampal neurogenesis in the animals even in inherited sleep-disturbed animals. The increased hippocampal neurogenesis functionally enhanced memory and learning functions by repeated PF oral administration. These results identify PF as a potential therapy for enhancing memory functions and prevention of Alzheimer's disease through actions on the hippocampus.
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
In conclusion, our results suggest that PF lead high hippocampal neurogenesis in the animals even in inherited sleep-disturbed animals. The increased hippocampal neurogenesis functionally enhanced memory and learning functions by repeated PF oral administration. These results identify PF as a potential therapy for enhancing memory functions and prevention of Alzheimer's disease through actions on the hippocampus.
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
AbstractObjectiveTo investigate the effectiveness and safety of manual acupuncture for memory loss and sleep quality in chronic insomniacs.MethodsA total of 60 eligible participants were enrolled and randomized into either a treatment group or a control group, with 30 cases in each group. The treatment group was intervened by manual acupuncture whereas the control group was given sham acupuncture. In the two groups, the interventions were offered once every other day and three times a week, for 8 weeks in total. Before and after the treatment, Pittsburgh sleep quality index (PSQI) and eventrelated potentials (ERPs) were us...
Source: Journal of Acupuncture and Tuina Science - Category: Complementary Medicine Source Type: research
This study is part of a growing body of research that suggests a sleep-deprived brain might be more vulnerable to Alzheimer’s disease. Animal studies have shown levels of plaque-forming A-beta plummet during sleep. Other research points to the fact that a sleeping brain runs the “clean cycle” (a reference to a dishwasher) to remove the day’s metabolic debris, specifically A-beta plaques. A study done in 2017 found that even one sleepless night appears to leave behind an excess of the troublesome protein fragment. While this is all impressive research, scientists believe there are still plenty of gap...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Health-related Mental Health and Wellness Research Sleep Alzheimer's disease Dementia Source Type: blogs
My grandfather was a true Yankee farmer. Taciturn and dignified, he rarely said a paragraph when a few words would do. Once, when I was in my mid-twenties and totally clueless about what it means to be dealing with old age, I found him sitting at the kitchen table translating poetry from German to English. Then in his late 70s, it had been over 50 years since he took basic German at the agricultural college he attended. I didn’t have any idea he knew even one German phrase. Yet there he was, diligently working out the poem, word by word by word. “Why don’t you just get an English translation?” I as...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Health-related Memory and Perception Self-Help Cognitive Function Memory Loss Source Type: blogs
Discussion Sleep disorders are common in all ages particularly sleep deprivation in our increasingly busy world. A review of health problems caused by inadequate sleep can be found here. Sleep problems are more common in patients with attention deficit hyperactivity disorder, epilepsy, headache and visual impairments. Sleep problems can cause cognitive and behavioral impairments including emotional regulation problems, increased seizures or headaches, and impaired attention and has been known to prolong recovery from various acquired brain injuries. Somnambulism or sleepwalking is a parasomnia (which include confusional a...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
This study is the clearest demonstration in humans that sleep disruption leads to an increased risk of Alzheimer’s disease through an amyloid beta mechanism,” said senior author Randall Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology. “The study showed that it was due to overproduction of amyloid beta during sleep deprivation.”More than 5 million Americans are living with Alzheimer ’s, a disease characterized by gradual memory loss and cognitive decline.What is the Difference Between Alzheimer ’s and DementiaThis study indicatesthat sleeping poorly...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: health lack of sleep alzheimer's lack of sleep dementia poor sleep linked to alzheimer Source Type: blogs
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