Proteomic Profiling of Exosomes Derived from Plasma of HIV-Infected Alcohol Drinkers and Cigarette Smokers

This study presents a proteomic analysis of plasma-derived exosomes from HIV-infected alcohol drinkers and smokers. Among the proteins altered due to drug-abuse, hemopexin and properdin were of highest significance. These proteins can be potential biomarkers for co-morbid conditions associated with drug abuse in HIV-patients.
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Publication date: June 2020Source: Materials Today Communications, Volume 23Author(s): S N Madhuri, M V Murugendrappa, K RukmaniAbstractConcentration dependent dielectric and electrical properties of PVA-Gd2O3 nanocomposite films over a wide range of frequencies (100Hz-1 MHz) and temperatures (303 K–423 K) is reported here. TEM of the Gd2O3 nanoparticles showed that they could be indexed to the cubic phase. The frequency variation of the dielectric permittivity and dielectric loss could be explained by the Maxwell Wagner Sillar’s model. The dielectric permittivity decreased in the composite films contrary to ob...
Source: Materials Today Communications - Category: Materials Science Source Type: research
Conclusion: Trauma is frequently associated with depression, anxiety disorders, somatoform pain disorder and PTSD in a clinical population. The clinical presentation and comorbidity of these disorders seem to vary significantly between traumatized patients with Norwegian, refugee and non-refugee immigrant backgrounds. After a major trauma, refugees may be at greater risk for both PTSD and depression than other immigrants and the native population. PMID: 31961250 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Publication date: 1 March 2020Source: Journal of Molecular Liquids, Volume 301Author(s): Reena, Abhinav Kumar, Vikas Mahto, Abhay Kumar ChoubeyAbstractPolymer gels have been proved useful for profile control and reducing excess water production from hydrocarbon-bearing reservoirs. In the present work, gels consisting of polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) and a blend of these two polymers (PVA and PVP) crosslinked with organic crosslinker was developed and studied. The optimum pH and polymer crosslinker ratio for gel systems was between 8 and 9 and the ratio was 1/0.25 respectively. The viscoelastic pro...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 21 January 2020Source: Journal of Molecular LiquidsAuthor(s): Stephanie MacDonald, Shannon MacLennan, D. Gerrard MarangoniAbstractThe thermodynamic parameters of surfactant/alcohol mixed micelles were determined in mixtures of sodium dodecyl sulfate (SDS) and dodecyltrimethylammonium bromide (DTAB) in a series of solvents composed of varying concentrations of n-propanol (C3OH), n-butanol (C4OH), and n-pentanol (C5OH). Conductivity studies were used to determine CMC values and the degrees of counterion binding. Isoperibol solution calorimetry was used to directly determine CMC values and e...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Conclusion: There was a high prevalence of MetS and abnormal ECG among the studied population. Abnormal ECG findings were more common in men with no differential association in people with or without MetS. However, a significant association existed between certain components of MetS and ECG abnormalities in men only. Male gender and HDLc were independent predictors of ECG Abnormalities.Keyword: Electrocardiography, metabolic syndrome, africans.
Source: African Health Sciences - Category: African Health Source Type: research
Background: The 2017 ACC/AHA Guideline categorized blood pressure into 4 levels:normal (SBP
Source: African Health Sciences - Category: African Health Source Type: research
Introduction: Hypertension is a cause and consequence of chronic kidney disease globally. The other factors that work in concert with hypertension to cause CKD are yet to be clearly elucidated. Studies have identified proteinuria, dyslipidemia, obesity, smoking and family history of CKD as renal risk factors. Due to the high morbidity and mortality associated with occurrence of CKD including the enormous financial burden involved in its management, the knowledge of prevention and understanding of the risk factors for development of CKD is highly essential. Therefore, Identifying well defined risk factors that display stron...
Source: African Health Sciences - Category: African Health Source Type: research
Background: Harmful alcohol use is a public health problem associated with negative health and socio-economic impacts. However, patterns and dynamics of alcohol use among slum-dwellers in Kenya are poorly understood.Objective: To establish determinants of harmful alcohol use among adults in an urban slum setting in Kenya.Materials and methods: Cross-sectional study involving a consecutively selected sample (N=215) from Githurai, in Nairobi. A pre-tested questionnaire that captured data on socio-demographics, drinking patterns, type, reasons, initiator, and support system.Results: Of the respondents, those above 31 years, m...
Source: African Health Sciences - Category: African Health Source Type: research
Publication date: Available online 21 January 2020Source: Process BiochemistryAuthor(s): Xiaoxia Jiang, Yafeng Zhou, Yun Zhang, Diying Tian, Su Jiang, Yunping TangAbstractThe present study was aimed at investigating the hepatoprotective effect of pyrroloquinoline quinone (PQQ) against acute alcoholic liver injury in mice. Acute alcoholic liver injury model was established in mice, and they were administrated with PQQ to investigate its hepatoprotective effect. Our results shows that PQQ can significantly ameliorate acute alcoholic liver injury by decreasing the hepatic marker enzymes, including serum alanine transaminase (...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
Publication date: 1 May 2020Source: Chemical Engineering Journal, Volume 387Author(s): Yuan Gao, Yang Zhou, Su-Yan Pang, Zhen Wang, Yong-Ming Shen, Jin JiangAbstractRecently, it has been reported that sulfur reducing agents (e.g., sulfite and thiosulfate) can effectively activate Fe(VI), leading to a fast degradation of various contaminants. However, the reactive intermediates (i.e., high-valent iron species versus free radicals) involved in the Fe(VI)/sulfite and Fe(VI)/thiosulfate systems remain far from clear. In this work, by using methyl phenyl sulfoxide (PMSO) as a mechanistic probe, we quantitatively assessed the re...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
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