FTY720 Inhibits MPP + -Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation

In conclusion, FTY720 may reduce PD progression by inhibiting NLRP3 inflammasome activation via its effects on ROS generation and p65 activation in microglia. These findings provide novel insights into the mechanisms underlying the therapeutic effects of FTY720, suggesting its potential as a novel therapeutic strategy against PD.Graphical AbstractFTY720 may reduce ROS production by inhibiting the PI3K/AKT/GSK-3 β signaling pathway, while at the same time reducing p65 phosphorylation, thus decreasing NLRP3 inflammasome activation through these two pathways, ultimately reducing microglia activation-induced neuronal damage.
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
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Source: Neurotoxicology - Category: Neurology Authors: Tags: Neurotoxicology Source Type: research
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Source: Journal of NeuroVirology - Category: Neurology Source Type: research
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Source: Neurochemistry International - Category: Neuroscience Source Type: research
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Source: Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Clin Immunol Source Type: research
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