Development of innate immunity in chicken embryos and newly hatched chicks: A disease control perspective.

Development of innate immunity in chicken embryos and newly hatched chicks: A disease control perspective.
Avian Pathol. 2019 May 07;:1-75
Authors: Alkie TN, Yitbarek A, Hodgins DC, Kulkarni RR, Taha-Abdelaziz K, Sharif S
Abstract
Newly hatched chickens are confronted by a wide array of pathogenic microbes when their adaptive immune defenses have limited capabilities to control these pathogens. In such circumstances and within this age group, innate responses provide a degree of protection. Moreover, as the adaptive immune system is relatively naïve to foreign antigens, synergy with innate defenses is critical. This review presents knowledge on the ontogeny of innate immunity in chicken pre-hatch and early post-hatch and provides insights into possible interventions to modulate innate responses early in the life of the bird. As in other vertebrate species, chicken innate immune system components, including cellular mediators, cytokine and chemokine repertoires and molecules involved in antigen detection, develop early in life. Comparison of innate immune systems in newly hatched chickens and mature birds has revealed differences, in magnitude and quality, but responses in younger chickens can be boosted using innate immune system modulators. Functional expression of pattern recognition receptors and several defense molecules by innate immune system cells of embryos and newly hatched chicks suggests that innate responses can be modul...

Source: Avian Pathology - May 6, 2019 Category: Pathology Authors: Alkie TN, Yitbarek A, Hodgins DC, Kulkarni RR, Taha-Abdelaziz K, Sharif S Tags: Avian Pathol Source Type: research