NLRP3 inflammasome activation is involved in trimethyltin-induced neuroinflammation.

This study aimed to assess the role of the nucleotide-binding oligomerization domain-like receptor pyrin-domain-containing protein 3 (NLRP3) inflammasome in TMT-induced central nervous system (CNS) injury. In addition, the mechanisms underlying TMT neurotoxicity are similar to those involved in the pathogenesis of multiple neurodegenerative diseases; hence, a study on TMT cytotoxicity may be informative for the understanding of human CNS diseases. Microglia were significantly activated in the rat hippocampal dentate gyrus after TMT treatment. The mRNA expression of pro-inflammatory cytokines, interleukin-1β and interleukin-18, was induced both in vitro and in vivo. TMT treatment activated the NLRP3 inflammasome in the microglial cell line BV2. NLRP3 RNA interference significantly protected these cells from TMT-induced neuroinflammation. Our results demonstrate that the NLRP3 inflammasome is a key mediator of neuroinflammation and plays an important role in TMT-induced neuroinflammation.
PMID: 31059678 [PubMed - as supplied by publisher]

Source: Brain Research - May 2, 2019 Category: Neurology Authors: Jianhai L, Qian W, Huanhuan H, Xin S, Guodong L, Shuai W, Jun Y, Pengsheng Y, Yuan L, Yongan W Tags: Brain Res Source Type: research