Diffusion tensor imaging of microstructural alterations in the trigeminal nerve due to neurovascular contact/compression

ConclusionThis study of trigeminal neuralgia due to NVC found that DTI indexes could reflect alterations in the affected trigeminal nerve. Furthermore, a reversible change after MVD surgery could be potentially valuable for monitoring the change in white matter of the trigeminal nerve.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research

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Authors: Persson J, Szalisznyó K, Antoni G, Wall A, Fällmar D, Zora H, Bodén R Abstract Pharmacological inhibition of phosphodiesterase 10A (PDE10A) is being investigated as a treatment option in schizophrenia. PDE10A acts postsynaptically on striatal dopamine signaling by regulating neuronal excitability through its inhibition of cyclic adenosine monophosphate (cAMP), and we recently found it to be reduced in schizophrenia compared to controls. Here, this finding of reduced PDE10A in schizophrenia was followed up in the same sample to investigate the effect of reduced striatal PDE10A on the neur...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
We present the rare case of a 47-year-old male long-distance runner who was referred to our hospital with a longstanding pain in his left calf. Clinical history, as well as ultrasound and magnetic resonance imaging scans, showed an accessory peroneal muscle. This muscle was identified as a peroneus quartus muscle. On ultrasound, controlled intracompartmental pressure measurement, a chronic peroneal compartment syndrome, was diagnosed. We performed an endoscopic-assisted fasciotomy of the peroneal compartment. This resolved the patient's symptoms completely and allowed the runner to return to competition shortly after the surgery.
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
ConclusionHere in this project, AAV vector with functional ABCD1 gene is constructed and its effectiveness is being tested in vitro for treating X-ALD. Meanwhile, a new animal model – ABCD1 gene mutated rabbit is used to mimic condition of X-ALD patients. Compared to the same age wild type rabbits, the diseased model shows a 5-10 folds increase in plasma VLCFA level before the treatment, and magnetic resonance imaging (MRI) scan is performed to determine demyelination inside the CNS.After AAV injection, rabbits' blood VLCFA level is monitored regularly, MRI scan and brain tissue sectioning are examined to determine t...
Source: Cytotherapy - Category: Cytology Source Type: research
Publication date: Available online 24 May 2019Source: NeuroImageAuthor(s): Amod Jog, Andrew Hoopes, Douglas N. Greve, Koen Van Leemput, Bruce FischlAbstractWith the advent of convolutional neural networks (CNN), supervised learning methods are increasingly being used for whole brain segmentation. However, a large, manually annotated training dataset of labeled brain images required to train such supervised methods is frequently difficult to obtain or create. In addition, existing training datasets are generally acquired with a homogeneous magnetic resonance imaging (MRI) acquisition protocol. CNNs trained on such datasets ...
Source: NeuroImage - Category: Neuroscience Source Type: research
This study aims to investigate the modulation effect of Baduanjin (a popular mind-body exercise) on MCI. 69 patients were randomized to Baduanjin, brisk walking, or an education control group for 24 weeks. The Montreal Cognitive Assessment (MoCA) and Magnetic Resonance Imaging scans were applied at baseline and at the end of the experiment. Compared to the brisk walking and control groups, the Baduanjin group experienced significantly increased MoCA scores. Amplitude of low-frequency fluctuations (ALFF) analysis showed significantly decreased ALFF values in the right hippocampus (classic low-freqency band, 0.01‐0.08 ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
DiscussionWe hypothesize that acupuncture can treat FC through normalizing the pathological alteration of the cerebral activity. The results of this trial will allow us to re-testify the therapeutic effects of acupuncture treating for FC and to investigate the potential central mechanism of acupuncture treatment for FC from direct (cerebral glucose metabolism) and indirect (contrast of oxyhemoglobin and deoxyhemoglobin) approaches.Trial registrationChinese Clinical Trial Registry,ChiCTR1800016658. Registered on 14 June 2018.
Source: Trials - Category: Research Source Type: clinical trials
Ventricular tachycardia (VT), which could lead to sudden cardiac death, occurs frequently in patients with myocardial infarction. Computational modeling has emerged as a powerful platform for the non-invasive investigation of lethal heart rhythm disorders in post-infarction patients and for guiding patient VT ablation. However, it remains unclear how VT dynamics and predicted ablation targets are influenced by inter-patient variability in action potential duration (APD) and conduction velocity (CV). The goal of this study was to systematically assess the effect of changes in the electrophysiological parameters on the induc...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
ConclusionsThese data suggest that altered cardiovascular hemodynamics after stage II influence brain growth and neurodevelopmental outcome in infants with HLHS/HLHC.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Accumulating evidence has shown that complicated brain systems are involved in the development and maintenance of chronic low back pain (cLBP), but the association between brain functional changes and clinical outcomes remains unclear. Here, we used resting-state functional magnetic resonance imaging (fMRI) and multivariate pattern analysis to identify abnormal functional connectivity (FC) between the default mode, sensorimotor, salience, and central executive brain networks in cLBP and tested whether abnormal FCs are related to pain and comorbid symptoms. Fifty cLBP patients and 44 matched healthy controls (HCs) underwent...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
We present the rare case of a 47-year-old male long-distance runner who was referred to our hospital with a longstanding pain in his left calf. Clinical history, as well as ultrasound and magnetic resonance imaging scans, showed an accessory peroneal muscle. This muscle was identified as a peroneus quartus muscle. On ultrasound, controlled intracompartmental pressure measurement, a chronic peroneal compartment syndrome, was diagnosed. We performed an endoscopic-assisted fasciotomy of the peroneal compartment.
Source: Journal of Foot and Ankle Surgery - Category: Orthopaedics Authors: Tags: Case Reports and Series Source Type: research
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