Effect of Serum Parathyroid Hormone on Tacrolimus Therapy in Kidney Transplant Patients: A Possible Biomarker for a Tacrolimus Dosage Schedule.

Effect of Serum Parathyroid Hormone on Tacrolimus Therapy in Kidney Transplant Patients: A Possible Biomarker for a Tacrolimus Dosage Schedule. Biol Pharm Bull. 2019;42(5):786-791 Authors: Hirata K, Watanabe H, Toyoda M, Sugimoto R, Ikegami K, Imafuku T, Matsuzaka K, Ichimizu S, Maeda H, Uekihara S, Jingami S, Maruyama T Abstract The mechanism responsible for the decreased extra-renal CYP3A activity in chronic kidney disease (CKD) patients remains unknown. Using an animal model, we previously found that elevated levels of serum intact parathyroid hormone (iPTH) caused a reduced CYP3A activity. This retrospective observational study assessed the relationship between serum iPTH levels and the blood concentration or dosage of tacrolimus, a CYP3A substrate, after oral administration in kidney transplant patients. Thirty-four patients were enrolled who had kidney transplants between April 2014 and March 2016 and who had been administrated once- daily prolonged-release tacrolimus (Graceptor®, Astellas Pharm Inc.). Among the 34 patients, 22 had taken a CYP3A inhibitor. These patients were excluded from the study. A significant positive correlation between serum iPTH and tacrolimus trough levels was found at 4 d before kidney transplantation in 12 patients who were not receiving potent CYP3A inhibitor. In addition, serum iPTH levels before transplantation could serve as a factor for the dose of tacrolimus up to 1 year after transplantation. Monitoring...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research

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As I begin my term as Chair of the Council on Renal Nutrition, I can ’t help but reflect on my journey to this point. I have been an registered dietitian nutritionist (RDN) for over 35 years and almost 20 of those years have been in the field of Nephrology. In caring for patients across the full spectrum of this specialty, I have worked with dialysis patients, pre -transplant and post-transplant patients, kidney donors, and CKD patients. I am currently employed in a multidisciplinary Chronic Kidney Disease Clinic.
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Message From the Chairperson Source Type: research
Conclusions: We identified key factors that increase the risk of ASE in patients with CKD. Opportunities exist to reduce ASE in CKD.Am J Nephrol
Source: American Journal of Nephrology - Category: Neurology Source Type: research
CONCLUSIONS: We identified key factors that increase the risk of ASE in patients with CKD. Opportunities exist to reduce ASE in CKD. PMID: 31216553 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: Am J Nephrol Source Type: research
ConclusionsRenal biopsies, while not commonly performed in children with SCD, were universally abnormal. Outcomes were poor in this cohort of patients despite a variety of post-biopsy interventions. Effective early intervention to prevent chronic kidney disease (CKD) is needed to reduce morbidity and mortality in children with SCD.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionsOur findings suggest that hypophosphatemia during the first 3  months after kidney transplantation was associated with better kidney survival.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
In this study, we pursued a candidate gene approach to measure WNT pathway genes in residual clinical FFPE biopsies with and without MVI. We focused on the WNT pathway because of previous translational studies that implicated this pathway in chronic renal allograft injury as well as vascular injury in native chronic kidney disease.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
(ERA-EDTA) As chronic kidney disease (CKD) progresses, the kidneys become less able to maintain a healthy balance of acids in the body. To maintain healthy acid levels, people with CKD are treated with alkaline substances such as sodium bicarbonate, also commonly used to neutralize heartburn and indigestion. The UBI study shows that sodium bicarbonate halves the risk of kidney disease progression, the likelihood of needing dialysis or transplantation) and overall mortality in people with CKD [1].
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Nature Reviews Nephrology, Published online: 13 June 2019; doi:10.1038/s41581-019-0161-4This Evidence-Based Guideline developed by members of the European Society for Paediatric Nephrology CKD-MBD, Dialysis and Transplantation working groups presents clinical practice recommendations for the use of growth hormone in children with chronic kidney disease on dialysis and after renal transplantation.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research
AbstractIntroductionChronic kidney disease (CKD) is a systemic disease affecting many organs. Progression of renal failure aggravates ongoing inflammation and increases oxidative stress. In the final stage of CKD, it is necessary to use renal replacement therapy. A side effect of dialysis therapy is the synthesis of proinflammatory factors and increased oxidative stress, which activates platelets and immune cells.Aim of the studyTo determine the regenerative potential of platelets in patients with CKD based on the analysis of the relationships between substances with potential regenerative action, as well as analysis of th...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionsThis study will examine the increasing prevalence of kidney diseases in HIV-positive adults in a West African population, and the relationship between these diseases and theAPOL1 high-risk genotype. By evaluating the addition of an ACEi to the care of individuals with HIV infection who have albuminuria, our trial will provide definitive evidence to guide strategies for management and clinical care in this population, with the goal of reducing HIV-related kidney complications.Trial registrationClinicalTrials.gov,NCT03201939. Registered on 26 August 2016.
Source: Trials - Category: Research Source Type: clinical trials
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