Vericel looks to market a gel for burns with new $142M licensing deal

Cambridge-based cell therapy firm Vericel Corp. has forged a $142 million deal to license a gel used to help heal burns that made just over $3 million in sales last year at an Israeli company. Vericel (Nasdaq: VCEL) will pay $17.5 million upfront and up to $125 million in milestones to license and sell the burn repair product NexoBrid from Israeli company MediWound Ltd., it announced Tuesday. The gel uses enzymes to remove burned tissue, with around 93 percent of subjects experiencing c omplete removal…
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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CONCLUSION: Blast related injuries of the hand during childhood are frequent and can cause different and complex defects. Besides prevention of these injuries, primary reconstruction of the affected hand is of outmost importance in preventing long-term consequences. PMID: 31537039 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
A gas explosion has sparked a fire at a Russian bioweapons facility which stores viruses including Ebola, smallpox and Anthrax. The blast occurred on Monday after a gas cylinder exploded during scheduled repair work on the fifth floor of the six-story Russian State Centre for Research on Virology and Biotechnology, commonly known as Vector, the facility said in a statement. No biological material was held in the sanitary inspection room where the explosion occurred, and no structural damage was caused to the concrete laboratory building, the center added. One worker was taken to hospital and is being treated in intensive c...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized onetime russia smallpox Source Type: news
Harry Campbell for TIME Climate change is a global challenge that demands global solutions. But we must acknowledge the fact that the most underresourced parts of the world are bearing the brunt of climate change, despite bearing the least responsibility for rising emissions. I have seen this with my own eyes in my native country of Mozambique. Earlier this year, Cyclones Idai and Kenneth wrought devastating havoc there and in neighboring Zimbabwe and Malawi. The city of Beira, one of the largest in Mozambique, was all but wiped from the face of the earth. Nationwide, more than 600 people were killed. The impact will be f...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Africa Climate 2019 climate change Source Type: news
Abstract Burns are a global public health issue of great concern. The formation of scars after burns and physical dysfunction of patients remain major challenges in the treatment of scars. Regenerative medicine based on cell therapy has become a hot topic in this century. Adipose-derived stem cells (ADSCs) play an important role in cell therapy and have become a promising source of regenerative medicine and wound repair transplantation. However, the anti-scarring mechanism of ADSCs is still unclear yet. With the widespread application of ADSCs in medical, we firmly believe that it will bring great benefits to pati...
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
ConclusionsThese findings suggest that degenerative MVr restores anticipated life expectancy to that of the general population, regardless of age. While our findings underscore the importance of repair for degenerative mitral disease, larger studies with longer-term follow-up are needed to reinforce this finding, particularly for younger patients.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Introduction: Options for therapy of severe burns are limited and generally include local wound care, debridement, grafting, and long-term care. Mesenchymal stem cells (MSCs) have been used in applications directed at the repair and regeneration of damaged tissue. There is little known regarding the clinical application of allogenic MSCs in the treatment of second degree burn injury. This pilot study establishes the safety of MSC therapy for burn wounds in two dose escalations, in addition to providing both observational and objective data that this treatment protocol improves the healing of these injuries.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Thermal injury leads to loss of the regenerative capacity of the skin and scarring becomes a significant risk, due to the inability to emulate normal skin architecture and adnexal structures. Mesenchymal stem cells (MSC) have been used in a variety of clinical applications to repair and regenerate damaged tissue. MSC ’s can stimulate cellular processes such as fibroblast proliferation, migration, and endothelial angiogenesis, as well as modulate the host’s immune response to favor more optimal wound healing.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
8/21/2019Mandy Cohen, M.D., MPH,Secretary, NC Department of Health and Human Services2001 Mail Service CenterRaleigh, N.C. 27699-2000Re: Randolph Hospital, Asheboro“I sat with my Anger long enough . . . until she told me her real name was Grief.”-UnknownDr. Cohen,A friend of a friend connected me to Sam Hedrick – who advised that if I composed a letter and e-mailed it to her, it would be put into the hands of the Secretary. This finished product is three weeks later than planned . . . because I briefly faltered . . . wondering (for good reason), “What IS the point?”. But I ...
Source: Dr.J's HouseCalls - Category: American Health Source Type: blogs
Publication date: Available online 17 August 2019Source: BurnsAuthor(s): Feng Tian, Yiwen Niu, Yuzhi JiangAbstractScar often occurred during wound repair. It was known that there were differences in collagen structure in dermal tissues at millimeter scale and micron scale, however, it was not known whether there were differences in collagen structure in dermal tissues at nanoscale during wound repair. In order to compare the difference at nanoscale, skin samples from patients were selected, the control groups were the normal skin from the same patients. These samples were tested by the small angle X-ray scattering techniqu...
Source: Burns - Category: Dermatology Source Type: research
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