Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD [Neuroscience]
GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). One class of major pathogenic molecules in C9ORF72-ALS/FTD is dipeptide repeat proteins such as poly(GR), whose toxicity has been well documented in cellular and animal models. However, it is...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Rodrigo Lopez-Gonzalez, Dejun Yang, Mochtar Pribadi, Tanya S. Kim, Gopinath Krishnan, So Yoen Choi, Soojin Lee, Giovanni Coppola, Fen-Biao Gao Tags: Biological Sciences Source Type: research
More News: Academies | ALS | Brain | Dementia | Gastroschisis Repair | Genetics | Neurology | Science | Toxicology