Vericel looks to market a gel for burns with new $142M licensing deal

Cambridge-based cell therapy firm Vericel Corp. has forged a $142 million deal to license a gel used to help heal burns that made just over $3 million in sales last year at an Israeli company. Vericel (Nasdaq: VCEL) will pay $17.5 million upfront and up to $125 million in milestones to license and sell the burn repair product NexoBrid from Israeli company MediWound Ltd., it announced Tuesday. The gel uses enzymes to remove burned tissue, with around 93 percent of subjects experiencing c omplete removal…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Jon Lorsch, from Swarthmore College’s class of 1990, returned to his alma mater in May to accept an honorary Doctor of Sciences degree for his accomplishments as a biochemist and his visionary leadership of NIGMS. During the university’s 147th commencement, he spoke to the 2019 graduating class, offering advice and examples of how we can look for opportunities in the least likely places. Watch the 5-minute video to hear Lorsch’s advice to the graduates—and all future scientists—to venture into the unknown in search of the next big advance in biomedical research. Transcript of Lors...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - Category: Research Authors: Tags: Being a Scientist Scientific Process Source Type: blogs
Authors: Zhang XG, Li XM, Zhou XX, Wang Y, Lai WY, Liu Y, Luo YC, Zhang JQ Abstract Callicarpa nudiflora has been widely used in Li nationality medicine and treated burns and scalds in China. Our objective was to preliminarily elucidate healing effect and action mechanism of Callicarpa nudiflora water extract (CNE) on the scald wounds using an experimental rat mode. The second-degree scald wounds were induced by hot water on dorsal surface of Sprague-Dawley (SD) rats, and then they were randomly divided into 5 groups as follows: control (CON), Vaseline, Silver sulfadiazine (SSD), and Vaseline supplemented with 10% ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Conclusion: Synechococcus elongatus PCC 7942 has the potential as a promising strategy for therapeutic angiogenesis and wound healing primarily by the delivery of functional EVs, not by its photosynthetic activity. The promotion of IL-6 expression may be a mechanism of the cyanobacterium and its EVs-induced pro-angiogenic and -wound healing effects.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Researchers at the Institute of Photonic Sciences (ICFO) in Catalonia have developed a new technique to decontaminate surgical meshes once they are implanted in the body. The technique involves gold nanoparticle-coated meshes that heat up when they a...
Source: Medgadget - Category: Medical Devices Authors: Tags: Nanomedicine Surgery Source Type: blogs
Conclusions Our cohort of patients following all-arthroscopic pre-tied suture device repair of isolated Palmer type 1B TFCC tears demonstrated excellent clinical function at a mean follow-up of 7 years. These findings indicate that the pre-tied suture device is a reliable, safe, effective, and most importantly, durable treatment option for repair of peripheral TFCC tears. Level of Evidence This is a Level IV, therapeutic study. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Wrist Surgery - Category: Orthopaedics Authors: Tags: Scientific Article Source Type: research
ConclusionThe effect of MAPC secretome on the capacity of keratinocytes, fibroblast and endothelial cells to migrate and proliferate was determined in vitro using scratch wound closure and WST1 assay respectively. Secretome-treated fibroblasts were also immunostained for collagen 1 and 3 to investigate its effect on matrix production. Additionally, second degree burns were created on the dorsal surface of mice (n=8/group) and 5 × 105 MAPCs in 100µl PBS were administered via intradermal injection to the wound margins, 24h post-burn injury. The burns were imaged daily until day 7, for macroscopic wound area d...
Source: Cytotherapy - Category: Cytology Source Type: research
What do you have in common with rodents, birds, and reptiles? A lot more than you might think. These creatures have organs and body systems very similar to our own: a skeleton, digestive tract, brain, nervous system, heart, network of blood vessels, and more. Even so-called “simple” organisms such as insects and worms use essentially the same genetic and molecular pathways we do. Studying these organisms provides a deeper understanding of human biology in health and disease, and makes possible new ways to prevent, diagnose, and treat a wide range of conditions. Historically, scientists have relied on a few k...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - Category: Research Authors: Tags: Genes Biofilms Cool Creatures Diseases Evolution Modeling Neurobiology Regeneration Research Organisms Wound Healing Source Type: blogs
In this study, a combination of hylauronic acid (HA) and ASCs (HA/ASCs) was applied on burn wounds and the injured area was then covered by an ADM dressing in a rat model (ADM‐HA/ASCs). Wound healing was evaluated by histopathological, histomorphometrical, molecular, biochemical, and scanning electron microscopy assessments on days 7, 14, and 28 post‐wounding. ADM‐HA/ASCs stimulated healing significantly more than the ADM‐HA and ADM treated wounds, as it led to reduced inflammation, and improved angiogenesis and enhanced granulation tissue formation. Expression of interleukin‐1β (IL‐1β) and transformi...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - Category: Materials Science Authors: Tags: ORIGINAL RESEARCH REPORT Source Type: research
In this study, the efficiency of bromelain-loaded chitosan nanofibers for burn wounds repair was investigated in animal model. Chitosan nanofibers containing bromelain (2% and 4% w/v) were prepared by electrospinning method. The physicochemical characteristics of the synthetized nanofibers were evaluated. The release profile and activity of bromelain loaded in nanofibers were also assayed. Cytotoxicity test was carried out using Alamar blue. The burn healing effect of chitosan-2% w/v bromelain nanofiber was studied in the induced burn wounds in rats for 21 days. The efficacy of treatment was assessed by reduction of burn...
Source: Life Sciences - Category: Biology Source Type: research
In this study, we have developed a triple-polymer scaffold made of collagen–elastin–polycaprolactone (CEP) composite, aiming to enhance the mechanical properties of the scaffold while retaining its biological properties in promoting cell attachment, proliferation and tissue regeneration. The inclusion of elastin was revealed to decrease the stiffness of the scaffold, while also decreasing hysteresis and increasing elasticity. In mice, electrospun collagen–elastin–PCL scaffolds promoted keratinocyte and fibroblast proliferation, tissue integration and accelerated early-stage angiogenesis. Only a mild...
Source: Burns - Category: Dermatology Source Type: research
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