New AlphaGRAFT DBM Fiber Technology Improves Regenerative Capacity

Optimized handling enables combination with allograft or autograft for use in spinal fusion procedures Provides moldable allograft with cohesive handling characteristics and osteoconductive scaffold for delivery of autologous stem cells Regenerative capacity exhibits all five elements of new bone formation in validated animal modelsThis story is related to the following:Surgical Implants
Source: Industrial Newsroom - Health, Medical and Dental Supplies - Category: Medical Devices Source Type: news

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Authors: Laurence J Abstract Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA) that is driven by uncontrolled activation of the alternative complement pathway, classically in the context of a genetic or autoimmune complement abnormality. Initial guidelines suggested lifelong treatment with the C5 inhibitor eculizumab, which until recently was the only therapy approved by the US Food and Drug Administration and European Medicines Agency for aHUS. However, multicenter observational studies provide compelling evidence that discontinuation of eculizumab, with careful monitoring for recurre...
Source: Clinical Advances in Hematology and Oncology - Category: Cancer & Oncology Tags: Clin Adv Hematol Oncol Source Type: research
Cytomegalovirus (CMV) infection is the most common clinically significant viral infection among CMV seropositive (R+) recipients of allogeneic hematopoietic cell transplant (HCT) [1]. CMV is associated with substantial morbidity and mortality, particularly in recipients of T-cell depleted (TCD) allografts and human leukocyte antigen (HLA)-mismatched or unrelated donor allografts [2-4]. The pre-emptive therapy (PET) approach is broadly used for CMV management [1]. In this approach, HCT recipients are routinely monitored for CMV post HCT and anti-viral therapy is initiated upon detection of CMV infection.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Large bone reconstruction is a major clinical issue associated with several challenges, and autograft is the main method for reconstructing large defects of maxillofacial bone. However, postoperative osteoporosis of the bone graft, even with sufficient vascularization, remains a primary problem. Therefore, better understanding of the mechanisms and clinical translation of bone homeostasis is required. Neuronal innervation of the bone is an emerging research topic, especially with regards to the role of peripheral nerves in regulating bone homeostasis. Moreover, sensory and autonomic nerves regulate this process via differe...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
Authors: PMID: 32619105 [PubMed - as supplied by publisher]
Source: Hip International - Category: Orthopaedics Tags: Hip Int Source Type: research
This study aimed to evaluate the quality and quantity of newly generated bone in the maxillary sinus grafted with stem cell-based allograft material.
Source: International Journal of Implant Dentistry - Category: Dentistry Authors: Tags: Research Source Type: research
In this study, we delivered gemcitabine monophosphate using lipid calcium phosphate nanoparticles, to desmoplastic pancreatic tumors. Monophosphorylation is a critical, rate-limiting step following cellular uptake of gemcitabine and precursor of the pharmacologically active gemcitabine triphosphate. Our drug delivery strategy enabled us to achieve robust tumor regression with a low parenteral dose in a clinically relevant, KRAS mutant, syngeneic orthotopic allograft, lentivirus-transfected KPC cell line-derived model of pancreatic cancer. Treatment with gemcitabine monophosphate significantly increased apoptosis of cancer ...
Source: The AAPS Journal - Category: Drugs & Pharmacology Source Type: research
Epidermolysis bullosa simplex (EBS) is an autosomal dominant skin fragility disorder caused by mutations in one of copolymeric keratins, keratin (K) 5 or K14. Current therapy for EBS is limited to wound care. However, the development of an experimental stem cell therapy using induced pluripotent stem cells (iPSCs) that can be genetically corrected, differentiated into new skin cells and administered back to the same patient as an autograft offers a promising new approach for EBS treatment. Toward this goal, we have previously combined our high-efficiency RNA-based reprogramming method with a Cas9-mediated gene correction s...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research
(Texas A&M University) Although most broken bones can be mended with a firm cast and a generous measure of tender loving care, more complicated fractures require treatments like bone grafting. Researchers at Texas A&M University have now created superior bone grafts using primitive stem cells. They found that these cells help create very fertile scaffolds needed for bone to regenerate at the site of repair.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
We read with interest the article by Arcuri et al. highlighting the importance of hematopoietic stem cell transplantation with specific conditioning regimens for aplastic anemia [1]. Allogenic hematopoietic stem cell transplantation (AHSCT) requires 4 to 6 weeks of hospitalization in the aim to prevent infectious complications. AHSCT has become a common practice in hematology centers – with for example around 15 000 allografts per year in Europe [2]. Visiting an allograft patient in a cleanroom obeys to strict hygienic measures such as washing the hands with an alcohol-based hand rub, maintaining social distancing, w...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: Letter to the Editor Source Type: research
A comparison of pre-clinical transplant models and of solid organs transplanted in routine clinical practice demonstrates that the liver is most amenable to the development of immunological tolerance. This phenomenon arises in the absence of stringent conditioning regimens that accompany published tolerizing protocols for other organs, particularly the kidney. The unique immunologic properties of the liver have assisted our understanding of the alloimmune response and how it can be manipulated to improve graft function and survival. This review will address important findings following liver transplantation in both animals...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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