Improving lung cancer treatment: Hyaluronic acid ‑modified and glutathione‑responsive amphiphilic TPGS‑doxorubicin prodrug‑entrapped nanoparticles.
Improving lung cancer treatment: Hyaluronic acid‑modified and glutathione‑responsive amphiphilic TPGS‑doxorubicin prodrug‑entrapped nanoparticles. Oncol Rep. 2019 May 02;: Authors: Lu G, Cao L, Zhu C, Xie H, Hao K, Xia N, Wang B, Zhang Y, Liu F Abstract Lung cancer nanotherapeutics aim to overcome the limitations of conventional therapeutic methods. In the present study, a self‑assembled amphiphilic prodrug‑based nanocarrier delivery system was developed that exhibited high therapeutic efficiency. D‑alpha‑tocopheryl polyethylene glycol 1000 succinate (TPGS) conjugated to doxorubicin (DOX) through disulfide (S‑S) bonds to constitute TPGS‑S‑S‑DOX was synthesized; furthermore, hyaluronic acid (HA) was conjugated to TPGS to obtain HA‑TPGS. TPGS‑S‑S‑DOX prodrug‑based and HA‑TPGS ligand‑modified nanoparticles (HA‑TPGS DOX‑NPs) were prepared for the treatment of lung cancer. In vitro and in vivo evaluation of the system was performed on lung cancer cell lines and lung tumor‑bearing mice. HA‑TPGS DOX‑NPs had a uniformly spherical shape with a white core and grey shell, with a size of 172.3 nm and a polydispersity index of 0.16. All of the NPs exhibited a drug encapsulation efficiency of>90%. The blank NPs exhibited low toxicity to all the tested cell lines, resulting in viabilities of>85%. HA‑TPGS DOX‑NPs had a more prominent in vitro antitumor effect than the other NPs tested, with cell viabilities of 80....
CONCLUSIONS: MiR-153 regulates gefitinib resistance by modulating expression of ABCE1 in lung cancers. Our findings may provide a worthwhile therapeutic target to reverse gefitinib resistance in lung cancers in the future. PMID: 31306106 [PubMed - as supplied by publisher]
Publication date: 5 December 2019Source: Journal of Molecular Structure, Volume 1197Author(s): S. Christopher Jeyaseelan, R. Premkumar, K. Kaviyarasu, A. Milton Franklin BenialAbstractThe FT-IR and FT-Raman spectra of 5-Methoxyindole-3-carboxaldehyde (MICA) molecule were recorded. The experimental and theoretical vibrational wavenumbers were assigned and compared. The non-linear optical (NLO) activity of the molecule was confirmed using second harmonic generation test and compared with theoretical result. The natural bond orbital (NBO) analysis was carried out to evaluate the intramolecular stabilization interactions of th...
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Conclusions/Implications for Practice A significant proportion of ever-smoker lung cancer patients in Taiwan will continue to smoke after receiving their diagnosis. Variables known to modify the risk factors associated with continued smoking such as regular exercise and better refusal self-efficacy should be considered and incorporated into future smoking cessation programs for patients with lung cancer.
Authors: Dana N, Karimi R, Mansourian M, Javanmard SH, Laher I, Vaseghi G Abstract Magnesium may reduce the risk of lung cancer by affecting cell proliferation, inflammation and by preserving lung function; however, the results of epidemiological studies on the potential benefits of magnesium in lung pathology are inconclusive. We conducted this meta-analysis to investigate the association between magnesium intake and the risk of lung cancer. A total of 5 studies were extracted from PubMed, SCOPUS, and the Cochrane Review (to May 2018). These studies involved 58,5821 participants with 8,977 lung cancer cases. The ...
(Massachusetts General Hospital) Massachusetts General Hospital (MGH) researchers identify markers that can distinguish between major subtypes of lung cancer and can accurately identify lung cancer stage.
ConclusionsThe study utilised a novel approach for reviewing an extensive and complicated body of research evidence. It enabled us to address a broad research question and focus on a specific area of priority. The staged approach ensured the review remained relevant to the stakeholders throughout, whilst maintaining the use of objective and transparent methods. It also provided important information on the needs of future research. However, it required extensive planning, management, and ongoing reviewer training.