125I radiation downregulates TRPV1 expression through miR ‑1246 in neuroblastoma cells.
125I radiation downregulates TRPV1 expression through miR‑1246 in neuroblastoma cells. Oncol Rep. 2019 Apr 22;: Authors: Zhang D, Xu H, Wang Y, Wang K, Wang Y, Wu B, Zhu J, Peng L, Gao J, Li Z Abstract Iodine‑125 (125I) seed radiation applied around the celiac ganglion can relieve the refractory pain in pancreatic cancer. In an in vitro cell radiation model of human neuroblastoma cell lines, the impact of 125I radiation on the expression of transient receptor potential vanilloid‑1 (TRPV1) was investigated. The results indicated that the radiation delivering doses 3.12 Gy significantly reduced cell viability. The reduced TRPV1 mRNA level was dependent on the doses, while the reduced protein level occurred at lower doses (2.63 and 4.27 Gy), then returned to normal at an intermediate dose of 5.09 Gy, and decreased again at higher doses (5.91 and 6.73 Gy). The miRNA profiling at the dose of 2.63 Gy revealed 32 and 22 miRNAs that were significantly upregulated and downregulated, respectively. In addition, the upregulated miR‑1246 target, regulated the expression of TRPV1, indicating that miR‑1246 may be a new therapeutic target for pancreatic pain. PMID: 31059092 [PubMed - as supplied by publisher]
39 y/o with triple-negative breast cancer, 1.9 cm in size, had lumpectomy after neoadjuvant chemo which showed complete response. I'm treating whole breast to 42.6/16. Would anyone omit boost? Thanks.
Authors: Licciardone JC, Schmitt ME, Aryal S Abstract Context: Comparisons of osteopathic physicians (ie, DOs) and allopathic physicians (ie, MDs) on interpersonal manner, including empathy and communication style, have been limited by such methodologic issues as self-assessment and a focus on medical students rather than practicing physicians. Objective: To compare perceptions of the interpersonal manner, empathy, and communication style of DOs and MDs and corresponding clinical measures reported by their patients. Methods: A cross-sectional study of adults with subacute or chronic low back pain was conduc...
Thereâs no doubt that the surgical robotics market is getting more crowded the competition is increasing. Intuitive Surgical, a pioneer in the space, is well aware of this fact and took steps this week to boost the da Vinci surgical robot. For an undisclosed sum, the Sunnyvale, CA-based company said it is acquiring the robotic endoscope portion of SchÃ¶lly Fiberopticâs business. SchÃ¶lly Fiberoptic is a player in the field of visualization systems for minimally invasive diagnostic and surgical applications, headquartered in Germany â and one of I...
Authors: Singh JR, Ibraheem K, Jain D, Yogendra K Abstract EBV associated nervous system complications includes encephalitis, meningitis, cerebellitis, polyradiculomyelitis, transverse myelitis, cranial and peripheral neuropathies, and psychiatric abnormalities are usually more commonly seen in immunocompromised patients and rarely in immunocompetent patients. Here we are reporting a 13 years old boy developed headache, malaise, sore throat and low back pain with radiation to both lower limbs. Next day he felt numbness below umbilicus followed by acute onset weakness in both lower limbs and urinary retention. Motor...
Authors: Bhushan D, Kumar R PMID: 31304717 [PubMed - in process]
Authors: Rustagi N, Pareek P, Verma M, Sharma PK Abstract Quality home-based care for patients with the end-stage disease is increasingly being preferred. Responding to disease associated symptoms and complications may pose an array of challenges in evolving palliative care systems, as no formal institutional mechanism exists to respond to patient and caregiver's wishes. Family and primary care physicians can play an instrumental role in such scenarios by bridging the gaps between cancer specialists and patient and caregivers expectations. PMID: 31304713 [PubMed - in process]
Alyssa Dyal was 23, a film student in Boston, fooling around with a guy she'd met on a dating app, when everything changed. Within months she was diagnosed with stage 4 breast cancer.
ConclusionsThe results confirm both the traditional use of O. campechianum and the importance of the leaf infusion as a potential source of antihyperglycemic agents. The isolation of 5-demethyl nobiletin (1) and 5-demethyl sinensetin (2) from O. campechianum and other Ocimum spp. suggests that polymethoxyflavones can be considered chemotaxonomical markers for the genus.Graphical abstract
ConclusionIn conclusion, this study showed that Aloe vera extract and its active component aloin activated the Wnt/β-catenin pathway and inhibited the Notch pathway in the presence of Wnt3a. While another active component, aloesin, activated the Wnt/β-catenin pathway and inhibited the Notch signaling pathway independent of Wnt3a. Given that Wnt/β-catenin and Notch pathway are closely associated with the progression of CRC, these findings would be helpful to better understand the colonic carcinogenicity of Aloe vera.Graphical abstract
XPOVIO is a drug used to treat a form of blood cancer called multiple myeloma. It is to be used in combination with dexamethasone (a type of corticosteroid) in patients with no other treatment options whose cancer came back after, or did not respond to, at least four previous treatments.