Cost-Effectiveness of the Use of Autologous Cell Harvesting Device Compared to Standard of Care for Treatment of Severe Burns in the United States

This study utilizes a health economic modeling approach to estimate cost-effectiveness and burn center budget-impact for the use of the RECELL® Autologous Cell Harvesting Device to prepare autologous skin cell suspension (ASCS) compared to standard of care (SOC) split-thickness skin graft (STSG) for the treatment of severe burn injuries requiring surgical intervention for definitive closure.MethodsA hospital-perspective model using sequential decision trees depicts the acute burn care pathway (wound assessment, debridement/excision, temporary coverage, definitive closure) and predicts the relative differences between use of ASCS compared to SOC. Clinical inputs and ASCS impact on length of stay (LOS) were derived from clinical trials and real-world use data, American Burn Association National Burn Repository database analyses, and burn surgeon interviews. Hospital resource use and unit costs were derived from three US burn centers. A budget impact calculation leverages Monte Carlo simulation to estimate the overall impact to a burn center.ResultsASCS treatment is cost-saving or cost-neutral (
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research

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ConclusionWe successfully treated a penile denudation with Manuka honey following a failed STSG. Wounds, ulcers, and burns may be infected, and can be challenging, time consuming, and expensive to treat. Manuka honey may be a good alternative to reconstructive surgery and can be managed on an out-patient basis.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Conclusions According to our results, “excision + radiation” had significantly better outcomes than excision alone. “Excision + pressure” had better outcomes than excision + any other treatment modality, and excision + nonradiation adjuvant therapies were also better than “excision only,” although these findings did not reach statistical significance.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research
Conditions:   Burns;   Skin Graft Complications;   Skin; Deformity Intervention:   Other: Suprathel or Xeroform donor site application Sponsors:   University of Colorado, Denver;   Children's Hospital Colorado Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Traveling to Mars, our closest planet and which may one day serve as another base for humanity, is very far away. Any practical mission there and back will take years. The health of the astronauts undertaking such a journey will be paramount, so rese...
Source: Medgadget - Category: Medical Devices Authors: Tags: Materials Plastic Surgery Rehab Space Medicine Source Type: blogs
The objective of this work was to study hydrogel dressings containing AgNPs from silver nitrate, synthesized by radiation involving the formation of silver nanoparticles with simultaneous occurrence of crosslinking and sterilization of the polymer systems. One of the hydrogels was prepared with poly(N-vinyl-2- pyrrolidone) (PVP) and the other with poly(vinyl alcohol) (PVA) as main studied polymers. An aqueous solution of AgNO3 was added to both polymer systems separately. The AgNPs synthesis, polymer crosslinking and dressing sterilization were achieved simultaneously by irradiating the resultant solutions with gamma-rays ...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
The 25-year-old man, known as Ramesh, said the surgery was 'nothing less than a miracle'. Surgeons in India used a skin graft with tissue, vessels and nerves. Later they will insert implants.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
We were very interested to read the correspondence by Sorooshian et al. in the March 2019 edition of JPRAS, comparing the use of keystone flaps and skin grafts for lower limb skin cancer reconstruction.1 The keystone perforator flap is widely reported as a robust and versatile local fasciocutaneous flap, with applications in the reconstruction of defects in the head and neck, within burns and over joints.5 Despite consensus that local flaps provide superior cosmetic and functional outcomes compared to split thickness skin grafts, we concur that there exists a relative sparsity of literature comparing objective and subjecti...
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Tags: Correspondence and Communications Source Type: research
We were very interested to read the correspondence by Sorooshian et al in the March 2019 edition of JPRAS, comparing the use of keystone flaps and skin grafts for lower limb skin cancer reconstruction.1 The keystone perforator flap is widely reported as a robust and versatile local fasciocutaneous flap, with applications in the reconstruction of defects in the head and neck, within burns and over joints.5 Despite consensus that local flaps provide superior cosmetic and functional outcomes compared to split thickness skin grafts, we concur that there exists a relative sparsity of literature comparing objective and subjectiv...
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Tags: Correspondence and Communications Source Type: research
ConclusionHealth professionals must consider this pathology when evaluating a burn scar or a chronic wound, performing a biopsy when suspicion is high. An early diagnosis, a prompt surgical intervention and a greater vigilance are the keys to success and survival.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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