Keratinocyte-derived TGF β is not required to maintain skin immune homeostasis

Transforming growth factor beta 1 (TGF β) is a pleiotropic cytokine belonging to the transforming growth factor superfamily [1]. TGFβ is secreted as a biologically inactive dimer. It becomes active when mature TGFβ disassociates from its latency associated peptide (LAP) [2]. Dissociation of LAP from TGFβ is primarily mediated by the RGD binding integrins αvβ6 and αvβ8 [3–5]. Active TGFβ binds to a heterodimeric TGFβ receptor complex and plays an essential role in cell cycle [6], tissue repair [7], and immune homeostasis and tolerance [8].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research