Anterior chamber associated immune deviation to cytosolic neural antigens avoids self-reactivity after optic nerve injury and polarizes the retinal environment to an anti-inflammatory profile

It has been hypothesized that anterior chamber-associated immune deviation (ACAID) to neural antigens induced prior to central nervous system injury can inhibit self-reactivity and lessen secondary degeneration. This work evaluated the effect of ACAID induced to three neural tissue-derived extracts (whole extract, cytosolic extract, CE; or organelle-membrane extract) prior to optic nerve injury on retinal ganglion cell (RGC) survival. The results show that only ACAID to the CE increased RGC survival at 7 and14 days post-injury (dpi).

Source: Journal of Neuroimmunology - May 6, 2019 Category: Allergy & Immunology Authors: L. Mart ínez-Alcantar, D.K. Talavera-Carrillo, J.U. Pineda-Salazar, M. Ávalos-Viveros, G. Gutiérrez-Ospina, B.V. Phillips-Farfán, A.L. Fuentes-Farías, E. Meléndez-Herrera Source Type: research