Implications of variation of epinephrine auto-injector needle length

In a series of papers, we have presented results from three primary papers (1-3) and two discussion papers (4,5) based on studies performed by Dr. Harold Kim ’s group in Ontario, Canada. High pressure epinephrine auto-injector (HPEAI) Epipen®/EpipenJr® (4) is the most commonly prescribed EAIs, in North America and Europe. Other HPEAI are Jext® (5) and Auvi-Q® (6). These EAIs require high pressure to release the needle and the dose of epinephrine. S ince there have been problems with possible periosteal/intraosseous injection in small children using HPEAIs, a HPEAI with shorter needle, Auvi-Q® 0.1 mg epinephrine (6.4 mm – 8.9 mm), has recently been introduced (6).
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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BOSTON (CBS) — It’s that time of year: kids are heading off to camp and the American Academy of Pediatrics is updating its recommendations on how to keep kids safe during the summer. First, all campers should have a pre-camp check-up with their pediatrician to address any health issues and update immunizations, whether it’s a day camp or an overnight camp. The AAP also suggested parents communicate directly with camp administrators to discuss any special health concerns, like food safety if a child has food allergies, or how daily medications will be stored and administered for kids who have underlying he...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated Local American Academy Of Pediatrics Dr. Mallika Marshall Summer Camp Source Type: news
ConclusionAllergic eczema/asthma in early life, being born during the autumn/winter, having multiple allergic symptoms and two allergic parents were all strong predictors for having allergic diseases at 5 and 10 years of age. However, the allergic march seems to be independent of heredity, as IgE ‐mediated allergies follow the same trajectories in children with and without allergic heredity.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL RESEARCH Source Type: research
AbstractPurpose of ReviewCharcot-Leyden crystals (CLCs), slender bipyramidal hexagonal crystals, were first described by Jean-Martin Charcot in 1853, predating Paul Ehrlich ’s “discovery” of eosinophils by 26 years. To date, CLCs are known as a classical hallmark of eosinophilic inflammation. CLC protein expresses palmitate cleaving lysophospholipase activity and is a member of the family of S-type lectins, galectin-10. We summarize current knowledge regarding t he pathological observations of CLCs and their mechanism of generation focusing on eosinophil cell death.Recent FindingsThe presence of CLCs...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
We read with great interest the recent review on epigenetic inheritance in patients with allergic disease.1 The evidence for epigenetic transmission of allergic disease across generations in human subjects is discussed by the authors. We have a few further comments, and some errors in the presented table need to be corrected.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
She and her husband identified an antibody that triggers wheezing and rashes. Monitoring it can help prevent and remedy allergic reactions.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Allergies Ishizaka, Teruko (1926-2019) Deaths (Obituaries) Asthma Hay Fever Ishizaka, Kimishige (1925-2018) Tokyo (Japan) La Jolla (Calif) Doctors Source Type: news
Publication date: Available online 13 June 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Pasquale Comberiati, Katie McCormack, Jonathan Malka-Rais, Joseph D. SpahnBackgroundMepolizumab is an anti–IL-5 antibody approved for the treatment of severe eosinophilic asthma. However, the prevalence of patients with severe asthma eligible for mepolizumab remains unknown, especially among children.ObjectiveTo determine, in a population of patients with severe asthma from a tertiary referral center, the proportion of patients with an eosinophilic phenotype who would be eligible for mepolizuma...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 13 June 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Evgenia Papathanasiou, Petros Bakakos, Georgios Hillas, Polyxeni Ntontsi, Myrto Blizou, Konstantinos Kostikas, Nikolaos Koulouris, Spyros Papiris, Stelios Loukides
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: In conclusion, we found evidence of the effect of ambient air pollutants on asthma hospitalizations in Shijiazhuang. The central heating period could modify the effects in terms of attributable risks. The disease burden modification of heating should be taken into consideration when planning intervention measures to reduce the risk of asthma hospitalization. PMID: 31200718 [PubMed - in process]
Source: Clin Med Res - Category: Research Authors: Tags: Respir Res Source Type: research
Bacterial lysate, a cocktail of 21 microbial species commonly used in Europe, purportedly decreases asthma and wheezing in children and specialists are taking notice.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news
Abstract KEY POINTS: Experimental maternal allergic asthma in sheep provides an experimental model in which to test impacts on progeny Fetuses from allergic asthmatic ewes had fewer surfactant-producing cells in lungs A greater proportion of lymphocytes from thymus were CD44 positive in fetuses from allergic asthmatic ewes than controls These changes to fetal development might contribute to poor neonatal lung function and increased risk of allergy seen in offspring of pregnancies complicated by asthma ABSTRACT: Asthma is prevalent in pregnancy and increases the risk of disease in offspring, including neonatal resp...
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research
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