Completion Rates, Adverse Effects, and Costs of a 3-Month and 9-Month Treatment Regimen for Latent Tuberculosis Infection in California Inmates, 2011-2014.

CONCLUSIONS: In an incarcerated population, the 3HP regimen had a higher completion rate, lower hepatotoxicity, and lower cost per fully treated patient than the 9H regimen. If coupled with a high treatment initiation rate, the high rate of LTBI treatment completion with 3HP may contribute to reducing tuberculosis morbidity in California. PMID: 31059418 [PubMed - in process]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research

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ConclusionsThe character of the periosteal reaction is clearly distinguishable from normal bone but is otherwise non ‐specific, with the exception of distinguishing direct pyogenic bone infection and those not directly related to infection and perhaps allowing identification of renal disease.
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
Publication date: Available online 24 February 2020Source: Respiratory InvestigationAuthor(s): Sze Shyang Kho, Swee Kim Chan, Mei Ching Yong, Hui Min Cheah, YC Gary Lee, Siew Teck Tie
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
J. van den Boogaard et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
In this study, we validated the functionality of a powerful Tn mutagenesis tool inMk and used this tool in conjunction with a forward genetic screen to establish a previously unrecognized role of a conserved mycobacterial small RNA gene of unknown function in colony morphology features and biofilm formation. We also combined Tn mutagenesis with next ‐generation sequencing to identify 12,071 Tn insertions that do not compromise viability in vitro. Finally, we demonstrated the susceptibility of theGalleria mellonella larva toMk, setting the stage for further exploration of this simple and economical infection model system ...
Source: MicrobiologyOpen - Category: Microbiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractSeveral rapid non-commercial culture-based methods and assays for drug susceptibility testing (DST) ofMycobacterium tuberculosis have emerged over the last decades. The aim of the current review was to summarise evidence on the performance of microscopic observation of drug susceptibility (MODS), thin-layer agar (TLA) and colorimetric redox-indicator (CRI) assays for detection of resistance to first- and second-line anti-tuberculosis (TB) drugs. Forty-three publications satisfying selection criteria were selected for data extraction. MODS and CRI assays demonstrated pooled sensitivity and specificity of> 93% for...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Conclusions: Functional occupational health surveillance systems can identify subgroups most at risk as well as areas of programme success and areas where increased support is needed, helping to target and monitor policy and procedure modification and training needs.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
AbstractMycobacterial pathogens can be categorized into three broad groups:Mycobacterium tuberculosis complex causing tuberculosis,M. leprae andM. lepromatosis causing leprosy, and atypical mycobacteria, or non-tuberculous mycobacteria (NTM), responsible for a wide range of diseases. Among the NTMs,M. ulcerans is responsible for the neglected tropical skin disease Buruli ulcer (BU). Most pathogenic mycobacteria, includingM. leprae, evade effector mechanisms of the humoral immune system by hiding and replicating inside host cells and are furthermore excellent modulators of host immune responses. In contrast,M. ulcerans repl...
Source: Seminars in Immunopathology - Category: Pathology Source Type: research
ConclusionVBN is helpful for the diagnosis of TBT-induced CBS and may provide important information on the location, length, diameter and cross-sectional area  of stenosis for further EOB examination and interventional therapy. VBN is recommended for patients with TBT and those with contradictions to bronchoscopy, as well as for regular follow-up of stable TBT, because it reduces the incidence of injury, avoids repeat operations and shortens treatment ti me.
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
Tuberculosis remains one of the leading causes of death from a single pathogen globally. It is estimated that 1/4 of the world’s population harbors latent tuberculosis, but only a 5–10% of patients will develop active disease. During latent infection, Mycobacterium tuberculosis can persist unaffected by drugs for years in a non-replicating state with low metabolic activity. The rate of the successful tuberculosis treatment is curbed by the presence of these non-replicating bacilli that can resuscitate after decades and also by the spread of M. tuberculosis drug-resistant strains. International agencies, includi...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
We read with great interest the paper by Safi et al. (1) describing frameshifts in glpK’s homopolymeric tract (HT) of seven cytosines (7C) as a potential cause of antibiotic tolerance. These results have implications for tuberculosis (TB) treatment, but other forces than antibiotic pressure may be responsible for the emergence...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Letters Source Type: research
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