Interleukin-17 expression in the serum and exfoliated cervical cells of patients infected with high-risk oncogenic human papillomavirus.
Interleukin-17 expression in the serum and exfoliated cervical cells of patients infected with high-risk oncogenic human papillomavirus.
Cytokine. 2019 May 01;120:92-98
Authors: Mareti Bonin C, Zatorre Almeida-Lugo L, Rodrigues Dos Santos A, Tezelli Junqueira Padovani C, Silva Pina AF, Teixeira Ferreira AM, Dos Santos Fernandes CE, Possati Resende JC, Bovo AC, Tozetti IA
Abstract
Persistent infection by high-risk oncogenic human papillomavirus (HR-HPV) is the main cause of cervical cancer and its precursor lesions, and both the systemic and local immunological responses play an important role in eliminating or maintenance this infection. Th17 cells, as well as interleukin (IL)-17, are related to tumor growth and persistence of viral infection. Thus, this study aimed to quantify IL-17 in the serum and exfoliated cervical cells of HR-HPV-infected patients and healthy patients as well as identify CD4+IL17+ cells and IL-17 production in uterine cervix biopsies to better understand the behavior of this cytokine in HPV infections. IL-17 was quantified (pg/mL) in the serum and exfoliated cervical cells of 26 HR-HPV-infected patients, and in 18 healthy patients, using flow cytometry. Fifteen paraffin-embedded biopsy samples from the uterine cervix were subjected to immunohistochemistry to detect CD4+IL-17+ and IL-17+ cells. There was a significant increase in the concentration of IL-17 in HR-HPV-positive patients' serum when compared to that...
Source: Cytokine - Category: Molecular Biology Authors: Mareti Bonin C, Zatorre Almeida-Lugo L, Rodrigues Dos Santos A, Tezelli Junqueira Padovani C, Silva Pina AF, Teixeira Ferreira AM, Dos Santos Fernandes CE, Possati Resende JC, Bovo AC, Tozetti IA Tags: Cytokine Source Type: research
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