Prevalence of in vitro synergistic antibiotic interaction between fosfomycin and nonsusceptible antimicrobials in carbapenem-resistant Pseudomonas aeruginosa.

CONCLUSION: Fosfomycin synergy was commonly observed in vitro among CRP. These data may guide the selection of combination antibiotic therapy. The susceptibility to other antibiotics was restored in combination with fosfomycin, warranting further in vivo evaluation. PMID: 31050629 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research

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Publication date: October 2019Source: The Journal of Steroid Biochemistry and Molecular Biology, Volume 193Author(s): Thijs A. Wolf, Sunil J. Wimalawansa, Mohammed S. RazzaqueAbstractEarly diagnosis of sepsis is often difficult in clinical practice, whilst it can be vital for positive patient outcomes in sepsis management. Any delay in diagnosis and treatment may lead to significant organ failure and can be associated with elevated mortality rates. Early diagnosis and effective management of sepsis can allow for prompt antibiotic therapy and a potential reduction in mortality; it can also minimize the unnecessary use of an...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
AbstractBackgroundAppropriate use of antimicrobials is essential to improve outcomes in sepsis. The aim of this study was to determine whether the use of a rapid molecular blood test —SeptiFast (SF) reduces the antibiotic consumption through early de-escalation in patients with nosocomial sepsis compared with conventional blood cultures (BCs).MethodsThis was a prospective, randomized, superiority, controlled trial conducted at Sao Paulo Heart Institute in the period October 2012 –May 2016. Adult patients admitted to the hospital for at least 48 h with a diagnosis of nosocomial sepsis underwent microorganis...
Source: Journal of Intensive Care - Category: Intensive Care Source Type: research
Publication date: Available online 19 July 2019Source: Research in Veterinary ScienceAuthor(s): Ivana Dalila Montironi, Elina BeatrizReinoso, Valentina Croce Paullier, María Inés Siri, María Julia Pianzzola, Melina Moliva, Noelia Campra, Guillermo Bagnis, Isabel Ferreira LaRocque-de-Freitas, Debora Decote-Ricardo, Celio Geraldo Freire-de-Lima, José María Raviolo, Laura Noelia CariddiAbstractMinthostachys verticillata essential oil (EO) is a natural product that reports immunomodulatory effects on human T cells as well as anti-inflammatory activity. Bovine mastitis is a worldwide disease, ...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
ConclusionsThese findings provide theory-informed evidence to support the development of antimicrobial stewardship interventions aimed at improving duration of antibiotic therapy.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Authors: Karaca S, Enercan M, Levent Ulusoy O, Hamaoglu A Abstract T55 patients with cement-augmented pedicle screw were retrospectively analyzed. All patients underwent computed tomography at a minimum of 2 years after index operation. Computed tomography scans were analyzed to determine pedicle screw loosening, cement leakage, and fusion rates at augmented levels. The purpose of this study was to analyze the efficacy and complications of cement augmentation in elderly patients. Screw loosening occurred at fused levels in all patients, except one patient with pseudoarthrosis. All cases of screw loosening occurred ...
Source: Acta Orthopaedica Belgica - Category: Orthopaedics Tags: Acta Orthop Belg Source Type: research
We report a case of agranulocytosis resulting from ceftriaxone noted more than 3 weeks into therapy. CASE PRESENTATION: A 72-year-old woman who was started on ceftriaxone for septic arthritis of the left knee 3 weeks before presentation was admitted to the hospital after being found to be neutropenic on outpatient laboratory analysis. Her absolute neutrophil count on admission was 0/μL. The cause of the agranulocytosis was suspected to be ceftriaxone. The drug was stopped, and she was started on granulocyte colony-stimulating factor with gradual resolution of the neutropenia. DISCUSSION: Serious adverse effects ...
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
Chronic low back pain (CLBP) is a condition that commonly consumes many resources and creates economic burden for the health care system. Evidence-informed care is crucial to guide management and prevent unnecessary procedures, including diagnostic imaging. Conservative therapy is currently recommended as the first-line and the most cost-effective treatment. Antibiotic therapy and surgical procedures are considered last resort treatment options for CLBP. The aim of this article is to summarize CLBP options for nurse practitioners (NP).
Source: The Journal for Nurse Practitioners - Category: Nursing Authors: Tags: Featured Article Source Type: research
AbstractLiterature for the treatment of hospitalized patients with community-acquired urinary tract infections (UTI) is limited. Previous outpatient studies do not support the use of oral beta-lactams compared with oral fluoroquinolones (FQ) due to poor clinical cure rates. However, recent studies evaluating intravenous (IV) beta-lactams in more complicated cases demonstrate promising cure rates. In addition, the use of more narrow-spectrum beta-lactams may be preferable when possible, due to a lower incidence of “collateral damage” compared with FQ. This was a retrospective, non-inferiority, single-center, coh...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Publication date: Available online 16 July 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Thijs Wolf, Sunil J. Wimalawansa, Mohammed S. RazzaqueAbstractEarly diagnosis of sepsis is often difficult in clinical practice, whilst it can be vital for positive patient outcomes in sepsis management. Any delay in diagnosis and treatment may lead to significant organ failure and can be associated with elevated mortality rates. Early diagnosis and effective management of sepsis not only allows for prompt antibiotic therapy and a potential reduction in mortality, it can also minimize the unnecessary u...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
ConclusionsOur preliminary experience suggests that intravesical administration of PRP should be considered as a feasible and safe option for the treatment of BK-induced HC after HSCT. Future studies are needed to assess its potential value in other forms of haemorrhagic cystitis.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
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