Screening of the Pathogen Box for the identification of anti-Acanthamoeba agents.

This study was aimed to evaluate the activity of the Medicines for Malaria Venture (MMV) compounds against the trophozoite stage of Acanthamoeba castellanii Neff. Sixteen compounds showed ≥ 90% inhibition of parasite growth in the initial screen (10 μM). Those set were further evaluated to determine the inhibitor concentration that inhibit the 50% of the initial population and cytotoxicity against murine macrophages. Among the compounds included in the pathogen box, pentamidine and posaconazole were the most effective against this parasite with an of IC50 of 0.567 ± 0.04 and 0.630 ± 0.11, respectively. PMID: 31059693 [PubMed - as supplied by publisher]
Source: Experimental Parasitology - Category: Parasitology Authors: Tags: Exp Parasitol Source Type: research

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Publication date: Available online 25 January 2020Source: International Journal of PharmaceuticsAuthor(s): Joan Puig-Rigall, Celia Fernandez-Rubio, Javier González-Benito, Judith E. Houston, Aurel Radulescu, Paul Nguewa, Gustavo González-GaitanoAbstractMiltefosine (MF), an alkylphospholipid originally developed for breast cancer treatment, is a highly active drug for the treatment against leishmaniasis, a neglected tropical disease considered the world’s second leading cause of death by a parasitic agent after malaria. MF exhibits dose-limiting gastrointestinal side effects in patients and its penetrati...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 25 January 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Sebastián Muñoz-Leal, José M. Venzal, Santiago Nava, Arlei Marcili, Daniel González-Acuña, Thiago F. Martins, Marcelo B. LabrunaAbstractA new argasid (Argasidae) tick is herein described based on morphology and molecular data obtained from larvae parasitizing Octodon degus and from ticks collected inside burrows in northern Chile. Unfed laboratory-reared larvae were mounted in slides for morphometrical and morphological analyses. Larvae of Ornithodoros octodontus n. sp. share morphological tr...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Authors: Fraenkel S, Salvioni OD, de Arias AR, Arze VP, Rolón M, Ramirez N, Vega Gómez C Abstract The Paraguayan Chaco is an isolated environment with its own unique ecosystem. In this region, Chagas disease remains a health problem. Chagas disease is caused by the parasite Trypanosoma cruzi, and it is primarily transmitted by triatomines. In order to identify the blood meal sources of triatomines, specimens of the vector were collected in residential and residential adjacent areas and the PCR-RFLP method was implemented. Cytochrome b was amplified from the samples and later subjected to digestion wit...
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research
Abstract Hosts that overlap geographically, are less phylogenetically divergent, and/or share similar ecological conditions (e.g., climate, habitat type) are also likely to share parasites. Here we assessed the ectoparasite communities sustained by 3 solitary species of Bathyergidae (Georychus capensis, Bathyergus suillus, and Bathyergus janetta) as well as the endoparasites exploiting G. capensis and compared them with those reported in the literature for other sympatric and parapatric African mole-rat species. In addition to 1 nematode ( Trichuris sp.) and 1 symbiotic ciliate (Meistoma georychi), we collected mi...
Source: The Journal of Parasitology - Category: Parasitology Authors: Tags: J Parasitol Source Type: research
Authors: Burgos-Blasco B, Arriola-Villalobos P, Ariño-Gutiérrez M, Gegúndez-Fernández JA, Díaz-Valle D PMID: 31973972 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Publication date: Available online 25 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Anais Laleve, Cristina Panozzo, Inge Kühl, Alexa Bourand-Plantefol, Jelena Ostojic, Abdoulaye Sissoko, Déborah Tribouillard-Tanvier, David Cornu, Angélique Burg, Brigitte Meunier, Marc Blondel, Jerome Clain, Nathalie Bonnefoy, Romain Duval, Geneviève DujardinAbstractArtemisinin and its derivatives kill malaria parasites and inhibit the proliferation of cancer cells. In both processes, heme was shown to play a key role in artemisinin bioactivation. We found that artemisi...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Publication date: Available online 24 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): María Carolina Amezcua Vesely, Constanza Rodriguez, Adriana Gruppi, Eva Virginia Acosta RodríguezAbstractHost resistance during infection with Trypanosoma cruzi, and other protozoans, is dependent on a balanced immune response. Robust immunity against these pathogens requires of the concerted action of many innate and adaptive cell populations including macrophages, neutrophils, dendritic cells, CD4+, and CD8+ T cells and B cells among others. Indeed, during most protozoan infec...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 24 January 2020Source: Journal of Theoretical BiologyAuthor(s): Min Su, Yuanqi Yang, Cang HuiAbstractBroad evidence has shown that host diversity can impede disease invasion and reduce the eventual prevalence, but little is known on how species interactions play in shaping this host diversity-disease relationship. Previous work has illustrated that intraguild predation (IGP), combined with parasite-mediated indirect effects, can have strong influences on parasitic infection. Following this line of thinking, we here examine the role of predatory interactions in the disease transmission wit...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
bina Eloit Moutailler Ticks transmit a wide variety of pathogens including bacteria, parasites and viruses. Over the last decade, numerous novel viruses have been described in arthropods, including ticks, and their characterization has provided new insights into RNA virus diversity and evolution. However, little is known about their ability to infect vertebrates. As very few studies have described the diversity of viruses present in ticks from the Caribbean, we implemented an RNA-sequencing approach on Amblyomma variegatum and Rhipicephalus microplus ticks collected from cattle in Guadeloupe and Martinique. Among...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Publication date: Available online 24 January 2020Source: Nano EnergyAuthor(s): Jing Ding, Wen-Quan Tao, Shih-Kang FanAbstractStructural parameter, such as device structure, and operational parameters, such as load resistance and droplet arrangement, were studied on the vibrational droplet triboelectric nanogenerators. Single-droplet devices with different structures were tested and theoretically analyzed. It is discovered that the device structure influences the output power by changing the triboelectric charge and the tribo/inductive capacitance ratio. The dependence of the optimal load resistance on the droplet number a...
Source: Nano Energy - Category: Nanotechnology Source Type: research
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