Effect of untreated pharmaceutical plant effluent on cardiac Na+-K+- ATPase and Ca2+-Mg2+-ATPase activities in mice (Mus Musculus)

Publication date: Available online 6 May 2019Source: Toxicology ReportsAuthor(s): A.O. Abdulkareem, T.F. Olafimihan, O.O. Akinbobola, S.A. Busari, L.A. OlatunjiAbstractCardiovascular diseases are major causes of death attributable to non-communicable diseases, throughout the world. Water pollution has been linked with the high global non-communicable disease burden but no report exists on the cardiotoxicity of pharmaceutical effluent, despite its indiscriminate discharge in to the aquatic environment in Nigeria, as in many other locations of the world. Thus, this study investigated the cardiotoxic effect of oral exposure to pharmaceutical effluent in mice. A total of thirty (30) male mice (Mus musculus) were randomly divided into 6 groups. Group A (control) received 0.2 ml distilled water, while groups B-F were treated with 0.2 ml 2.5%, 5.0%, 10.0%, 20.0% and 40% concentrations (v/v, effluent/distilled water) of the effluent respectively for 28 days. Significant reductions (p
Source: Toxicology Reports - Category: Toxicology Source Type: research

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