Zingiber officinale (Roscoe) mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentials

This study investigated the effects of methanol extract of Zingiber officinale (Roscoe) rhizome (MEZOR) in a Wistar rat model of carbon tetrachloride (CCl4)-induced liver injury. The study recruited thirty female Wistar rats that received graded doses of MEZOR (determined by its LD50) by oral gavage through an oral canula, for 4 consecutive weeks following 1 week oral administration of CCl4 (0.7 ml/kg in olive oil; 1:1, v/v) while livolin forte® (5.2 mg/kg p.o.) was used as a standard. CCl4 induced deleterious hepatic effects as revealed by the liver function biomarkers (AST, ALT, ALP and total protein), antioxidant indicators (GSH and CAT) and histopathological effects, demonstrated by H &E, Gordon and Sweet, Masson’s trichrome, PAS staining techniques as well as by quantificational analyses of the liver micrographs, using image–J. MEZOR treatment was associated with a dose-dependent and significant mitigation of the aforementioned parameters (p 
Source: Toxicology Reports - Category: Toxicology Source Type: research

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While the discovery of the normally microbe-produced phosphine on our toxic neighbour is astonishing, other candidates for life are more promisingIt remains one of the most unexpected scientific discoveries of the year. To their astonishment, British scientists last week revealedthey had uncovered strong evidence that phosphine – a toxic, rancid gas produced by microbes – exists in the burning, acid-drenched atmosphere of Venus.Related:If we don't find life on planets like Venus, doesn't it make us that bit more special? | Charles CockellContinue reading...
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