Is leptin receptor gene (Gln223Arg) polymorphism associated with disease susceptibility and severity in patients of primary knee osteoarthritis?

ConclusionLeptin receptor gene (Gln223Arg) SNP might be associated with severity of KOA. There is a significant genetic association between the SNP and BMI hence, LEPR SNP might be indirectly associated with the incidence of KOA. Furthermore, the SNP is not directly associated with KOA susceptibility in the Egyptian population.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research