Ask Who Is at High Risk for Emphysema

Who Is at High Risk for Emphysema?
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Conclusions: CT-derived lobar volume and emphysema quantification using the LungSeg program is efficient and reliable in allowing lobar volume assessment. LungSeg has low inter-user variability and agrees better with plethysmography for COPD assessment in our study.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
Some potential causes of shortness of breath when lying down include heart failure, obesity, and emphysema. Learn more about the causes of shortness of breath when lying down here, along with their treatment options.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Respiratory Source Type: news
Elastin breakdown and the resultant loss of lung elastic recoil is a hallmark of pulmonary emphysema in susceptible individuals as a consequence of tobacco smoke exposure. Systemic alterations to the synthesis...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
AbstractAugmentation therapy with human α1-proteinase inhibitor (Respreeza®) is an effective and generally well tolerated treatment option for patients with severe α1-antitrypsin deficiency. In the 2-year RAPID trial, intravenous Respreeza 60  mg/kg once weekly was associated with a trend towards reduced mean annual rate of lung density loss (as measured by computed tomography) at total lung capacity (TLC) and functional residual capacity (FRC) combined, and at FRC alone, with a significant reduction seen at TLC alone. The continued eff icacy of Respreeza in slowing the progression of emphysema was dem...
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
Publication date: 5 November 2019Source: Journal of Molecular Structure, Volume 1195Author(s): Tooba Siddiqui, Mohammad Khalid Zia, Syed Saqib Ali, Haseeb Ahsan, Fahim Halim KhanAbstractHydrogen peroxide (H2O2) is an important signalling molecule and a non-radical reactive oxygen species (ROS) which can convert into more potent oxygen radicals leading to oxidative stress. The correlation between oxidative stress and the cellular proteinase-antiproteinase balance has been a major component in the development of several pathologies such as emphysema and cystic fibrosis. The present studies attempt to explore the functional i...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, we show that respiratory diseases are associated with changes in swallowing–ventilation coordination and hypothesize that they increase the risk of aspiration.
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research
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Source: FEBS Letters - Category: Biochemistry Authors: Tags: Communication Source Type: research
Authors: Mal H, Bunel V, Marceau A, Dombret MC, Debray MP, Crestani B Abstract Lung hyperinflation which is a hallmark of advanced emphysema plays a major role in the exertional dyspnoea experienced by patients. This has led to the development of surgical lung volume reduction which, though effective, is also associated with significant morbidity and mortality. The goal of endoscopic lung volume reduction which has developed over several years is to decrease hyperinflation without exposing patients to the risks of surgery. Several endoscopic techniques have been assessed by high quality controlled studies: airway b...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Conclusions: UA attenuated CSE-induced emphysema and airway remodeling, exerting its effects partly through regulation of three UPR pathways, amelioration downstream apoptotic pathways, and alleviating activation of Smad2 and Smad3.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: CPET may greatly facilitate the diagnosis of unexplained dyspnoea. More than 50% of the dyspnoea cases examined here were due to deconditioning or hyperventilation syndrome and would benefit from a simple pulmonary rehabilitation program. PMID: 31204232 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
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