Time-Course Effects of Acute Aflatoxin B1 Exposure on Hepatic Mitochondrial Lipids and Oxidative Stress in Rats

This study revealed that AFB1 disrupts hepatic mitochondrial lipids and antioxidant capacity. These changes were dependent on the timing of exposure and did not follow a linear time-course trend. These alterations could be part of the hepatic mitochondria response mechanism to acute AFB1 toxicity. Aflatoxin B1; Liver; Mitochondria; Lipid; Cholesterol; Thioredoxin reductase; oxidative stress
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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ConclusionsThe relevance of SPARC expression in pancreato-biliary carcinomas though may still be important for therapeutic decision making, it is not responsible for peritumoral stromal desmoplasia in these tumors and it does not have any significant prognostic implication.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
We present for the first time a case of MFS of the breast induced by radiotherapy.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionsThe present study has verified the ethnomedical use of C. mas for the treatment of ulcerative colitis.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Basosquamous carcinomas (BSCs), which comprise 1.2 –2.7% of skin carcinomas, are aggressive skin tumors that feature histopathologic characteristics of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BSC origin and genetic etiology remain controversial. Chiang and colleagues reported underlying PTCH and SMO mutations in BSCs, su ggesting that Hedgehog signaling drives BSC similar to BCC. Principal component analysis indicated that BSC has greater genetic similarity to BCC than to SCC, supporting the concept that BSCs are derived from BCCs.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Clinical Snippets Source Type: research
Basosquamous carcinoma (BSC) is a rare form of skin cancer with both basaloid and squamous morphology. Chiang et  al. (2019) genetically define BSCs and demonstrate that BSCs likely originate as basal cell carcinomas that partially squamatize through accumulation of ARID1A mutations and RAS/MAPK pathway activation.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research
In the present study, the hepatoprotective, antioxidant and cytotoxic activities of aqueous extract of turmeric rhizome (Turmesac) were evaluated. In brief, Turmesac was extracted from turmeric rhizome. 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay was used to evaluate the hepatoprotective and cytotoxic activities of the Turmesac against the human liver (HUH-7) and...
Source: Journal of Medicinal Plants Research - Category: Complementary Medicine Source Type: research
CONCLUSION: In renal tumor care, renal biopsy is a reliable testing. However, some factors most likely linked to the tumor anatomy (intra-sinusal tumor) and their histological composition were involved in the lack of non-contribution to the diagnosis. LEVEL OF EVIDENCE: 4. PMID: 31629660 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Publication date: Available online 20 October 2019Source: Seminars in Cancer BiologyAuthor(s): Laurence A. Booth, Jane L. Roberts, Paul DentAbstractThe molecular mechanisms by which tumor cells survive or die following therapeutic interventions are complex. There are three broadly defined categories of cell death processes: apoptosis (Type I), autophagic cell death (Type II), and necrosis (Type III). In hematopoietic tumor cells, the majority of toxic stimuli cause these cells to undergo a death process called apoptosis; apoptosis specifically involves the cleavage of DNA into large defined pieces and their subsequent loca...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
ConclusionsMyeloma patients seem to be highly adherent  to IMID treatments.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Authors: Davaro F, May A, McFerrin C, Raza SJ, Siddiqui S, Hamilton Z Abstract INTRODUCTION: To evaluate the overall survival and pathologic downstaging effect of neoadjuvant chemotherapy for upper tract urothelial cell carcinoma. MATERIALS AND METHODS: The National Cancer Database (NCDB) was queried for patients with stage II-IV upper tract urothelial cell carcinoma undergoing definitive surgical resection (nephroureterectomy) from 2004-2015. Patients with metastatic disease were excluded. Cohorts were stratified by receipt of neoadjuvant chemotherapy (NAC). Kaplan-Meier analysis and Cox regression were used t...
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
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