Time-Course Effects of Acute Aflatoxin B1 Exposure on Hepatic Mitochondrial Lipids and Oxidative Stress in Rats

This study revealed that AFB1 disrupts hepatic mitochondrial lipids and antioxidant capacity. These changes were dependent on the timing of exposure and did not follow a linear time-course trend. These alterations could be part of the hepatic mitochondria response mechanism to acute AFB1 toxicity. Aflatoxin B1; Liver; Mitochondria; Lipid; Cholesterol; Thioredoxin reductase; oxidative stress
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research