The First Pathological Specimen from a Rare Local Reaction after Subcutaneous Allergen Immunotherapy

We describe a curious and rare case of bullous vesicles forming in a delayed local reaction to SCIT. We also provide and discuss the pathological results of shave and punch biopsies obtained from this reaction in order to consider a possible mechanism of action.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research

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CONCLUSION: A similar approach to that used for peanut OIT can be taken for non-peanut foods, and for multiple foods simultaneously. High baseline allergy test results are not a contraindication to OIT. PMID: 31494236 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
A 21-year-old man with chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and comorbid asthma the last ten years was referred for allergy evaluation. The diagnosis of CRSwNP was based on the patient ’s symptomatology (nasal congestion, atypical facial pain, hyposmia/anosmia), nasal endoscopy, and the objective evidence of mucosal inflammation (complete opacification of the paranasal sinuses on CT-scan that revealed marked mucosal thickening with partial opacification of right maxillary sinus, near complete opacification of left maxillary sinus, and complete opacification of right and left frontal and anterior et...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Challenging Clinical Cases Source Type: research
The basis of venom immunotherapy (VIT) can be defined as protection against IgE-mediated immunologic mechanisms such as anaphylaxis.1,2 Most insect stings produce local reactions of swelling, pain, erythema and pruritus, typically peaking by 24-48 hours and resolving within 3-10 days.5 Unfortunately, some patients experience systemic reactions ranging from cutaneous reactions only (characterized by urticaria and/or angioedema, excluding throat, larynx and tongue) to life-threatening systemic anaphylactic reactions (SAR).
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Fifty percent glycerin is often used in allergen immunotherapy (AIT) extracts to preserve extract potency.1 However, glycerin is also an irritant and it is recommended to dilute glycerin to reduce pain and inflammation associated with immunotherapy.2, 3 The 2011 allergen immunotherapy practice parameter warns that “higher glycerin concentrations are associated with injection pain, which correlates with the total amount of glycerin injected.”4 To date, two studies evaluating the role of glycerin during allergen immunotherapy differed regarding their methods and conclusions.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
We describe a case of bullous vesicles forming in a delayed local reaction to SCIT. We also provide the results of biopsies to consider possible mechanisms of action.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: M019 Source Type: research
Pain, local reactions and the fear of anaphylaxis due to inadvertent intravenous administration limit the use of subcutaneous immunotherapy (SCIT) in children. We evaluate its tolerability when delivered by a needleless device.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusions: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685 Received: 19 June 2016 Revised: 07 June 2017 Accepted: 19 June 2017 Published: 13 September 2017 Address correspondence to N. Sang, College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, P...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder characterized by esophageal dysfunction and eosinophilic infiltration of the esophageal mucosa. The disease affects both children and adults, with a prevalence of 5 per 10,000 inhabitants in Europe and the United States.1 Childhood cases are generally diagnosed between 5 and 10 years of age and adult cases between 30 and 40 years of age. The male-female sex ratio is 3:1 in a published series.2 The symptoms vary according to the age of the individual and consist of difficulties in feeding and in gaining weight in small children, abdominal pain and vomiting in...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letter Source Type: research
Conclusions In a Midwestern referral population, chronic vaginitis compounded by inhalant allergy showed: (1) high incidence rate of recurrent vulvo-vaginal candidiasis, (2) Candida IgE-mediated sensitization in less than one-third of patients with recurrent vulvovaginal candidiasis, (3) comorbid conditions not dissimilar to those of other allergic patients, and (4) allergen sensitization pattern typical for the Midwest.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Allergen immunotherapy is the only treatment that can treat the cause of the allergy. Rapid desensitization (or ultrarush) allow saving time. However, there are the same tolerance than classic immunotherapy ?We have made a prospective study in the department of pneumology in military hospital of Tunisia. We collected 46 children for a period of one year and falling comparing the safety of sublingual immunotherapy Ultra-Rush (n = 28) with the classical subcutaneous immunotherapy (n = 18).The mean age was 8.21 years ( 3-13 years). We had 32 (69%) male and 14 (30%) female. A family atopy was noted in 22 (47%). Active smoking ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 5.3 Allergy and Immunology Source Type: research
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