Decrease of tetrahydrobiopterin and NO generation in endothelial cells exposed to simulated diving.

Conclusion: NO generation in intact human endothelial cells was decreased by simulated diving, as well as by hyperoxic exposure, while BH4 levels seem to be affected only by hyperoxia. Hence, the results suggest that BH4 is not the sole determinant of NO generation in HUVEC.
PMID: 31051061 [PubMed - in process]

Source: Undersea and Hyperbaric Medicine - February 28, 2019 Category: Sports Medicine Authors: Hesthammer R, Eide T, Thorsen E, Svardal AM, Djurhuus R Tags: Undersea Hyperb Med Source Type: research