Fractal analysis and mathematical models for the investigation of photothermal inactivation of Candida albicans using carbon nanotubes

Publication date: Available online 6 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Kevin F. dos Santos, Marcos S. Sousa, João V.P. Valverde, Clarissa A. Olivati, Paula C.S Souto, Josmary R. Silva, Nara C. de SouzaABSTRACTCandida albicans is responsible for the majority of nosocomial infections affecting immunocompromised patients. Systemic antifungals may promote microbial resistance, which has led to the search for alternative treatments, such as photothermal therapy (PTT). PTT assumes that the interaction of electromagnetic radiation with a photothermal agent generates heat that can lead to the destruction of tumor cells and the death of microorganisms. Carbon nanotubes (CNTs) have the potential for applications in biomedical systems, including acting as controlled deliverers of drugs, biosensors and scaffolds for tissue engineering and regenerative medicine. Furthermore, the absorption of radiation by CNTs in the infrared region induces an increase in temperature, which makes CNTs candidates for photothermal agents. In this work, the photothermal inactivation of C. albicans was evaluated by multiple wall CNTs associated with laser radiation in the near-infrared region. The mechanisms that are involved in inactivation were evaluated through cell susceptibility studies and an analysis of microscopic images that are associated with mathematical models and fractal concepts. The results indicate that direct contact between the cells and CNTs without irradiat...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research