Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI.

Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI. Exp Neurol. 2019 May 02;: Authors: Sta Maria NS, Sargolzaei S, Prins M, Dennis E, Asarnow RF, Hovda DA, Harris NG, Giza CC Abstract Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may also provide adaptability and potential for recovery. This review will examine and synthesize our current understanding of developmental neurobiology in the context of pediatric TBI. Delineating this biology will facilitate more targeted initial care, mechanism-based therapeutic interventions and better long-term prognostication and follow-up. PMID: 31055004 [PubMed - as supplied by publisher]
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

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