Differential status and significance of non-enzymatic antioxidants (reactive oxygen species scavengers) in malaria and dengue patients.

Differential status and significance of non-enzymatic antioxidants (reactive oxygen species scavengers) in malaria and dengue patients. Acta Trop. 2019 May 01;: Authors: Aqeel S, Naheda A, Raza A, Khan K, Khan W Abstract An imbalance in oxidants and antioxidants is observed during malaria and dengue infections which is associated with the production of reactive oxygen species (ROS) via haem degradation or immune activation, a contributing factor for disease pathogenesis. The levels of non-enzymatic antioxidants and total antioxidant status (TAS) in malaria and dengue patients were analysed and compared with healthy controls. Particular attention was paid to elevated levels of total bilirubin (TB) and uric acid (UA) during disease progression and haemolysis and noticed a significant increase in dengue patients (dengue>Pf>Pv>control). A highly significant difference was also observed between dengue and Pf patients (p < 0.0001) for these parameters. Glutathione levels were comparable in dengue and falciparum malaria but were significantly higher than that of vivax malaria patients. Ascorbate levels were significantly depleted in all the patient groups (p < 0.0001) and a negative correlation was established for TAS and ascorbate levels in dengue patients (r=-0.32). A good positive correlation was observed between TAS-UA and TAS-TB levels. Thus, these findings suggest that severe haemolysis, renal failure, and liver...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research