Guidelines Address Juvenile Idiopathic Arthritis Management

MONDAY, May 6, 2019 -- Recommendations have been developed for both uveitis in juvenile idiopathic arthritis (JIA) and JIA manifesting as nonsystematic polyarthritis, sacroiliitis, or enthesitis; the two guidelines were published online April 25 in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Publication date: Available online 15 October 2019Source: Best Practice &Research Clinical RheumatologyAuthor(s): Patrícia Martins, João Eurico FonsecaAbstractMultiple studies have shown that there is a pre-clinical period preceding the development of rheumatoid arthritis (RA). During this period, complex interactions between the environmental and genetic causes occur, and the expression “preclinical RA” has been proposed to define it. Early treatment intervention is associated with less joint damage and has an increased possibility of achieving remission. In this review, we provide an overvie...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
A theme of recent years is the discovery of processes of regrowth that operate in mammalian tissues long thought to be non-regenerative. In this case, researchers have found a mechanism of regeneration that operates in cartilage, albeit not to the degree that would be helpful for recovery from more serious injury or the wear of aging. Still, where a mechanism exists at all, it should be possible to find ways to enhance its operation. This work is interesting for the resemblance that this regenerative process bears to the way in which salamanders regrow lost organ tissue. Finding ways to bring that sort of exceptional regen...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
l;nke G Abstract Mononuclear phagocytes, including monocytes and macrophages, are a central component of the host's innate immune system designated to protect against invading pathogens. However, these cells do not only interact with various parts of the innate and adaptive immune system, but also fulfill indispensable duties during the control of tissue homeostasis and organ function. Moreover, macrophages are crucially involved in tissue remodeling and repair in response to damage. Simultaneously, mononuclear phagocytes might also contribute to the pathogenesis of various inflammatory and autoimmune diseases. In...
Source: Advances in Immunology - Category: Allergy & Immunology Authors: Tags: Adv Immunol Source Type: research
Publication date: Available online 14 October 2019Source: Life SciencesAuthor(s): Gleison Daion Piovezana Bossolani, Bruna Thais Silva, Juliana Vanessa Colombo Martins Perles, Mariana Machado Lima, Flávia Cristina Vieira Frez, Sara Raquel Garcia de Souza, Camila Caviquioli Sehaber-Sierakowski, Ciomar Aparecida Bersani-Amado, Jacqueline Nelisis ZanoniAbstractAimsThe aim of our study was to study the pathological mechanisms induced by the rheumatoid arthritis (RA) on the Enteric Nervous System (ENS).Main methodsWe evaluated the effect of the chronic arthritis and its treatment with 50 mg/kg quercetin alone (AQ) and ...
Source: Life Sciences - Category: Biology Source Type: research
In this study, we found that the water extracts of Boseokchal (BSC-W) inhibited osteoclast differentiation in vitro and investigated its inhibitory mechanism. BSC-W was obtained by extracting flour of Boseokchal using hexane and water. To osteoclast differentiation, bone marrow-derived macrophage cells (BMMs) were cultured with the vehicle (0.1% DMSO) or BSC-W in the presence of M-CSF and RANKL for 4 days. Cytotoxicity was measured by CCK-8. Gene expression of cells was confirmed by real-time PCR. Protein expression of cells was observed by western blot assay. Bone resorption activity of osteoclast evaluated by bone pit fo...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ConclusionsThe hypoglycemic mechanism of DOP might be associated with the regulation of glucagon-mediated hepatic glycogen metabolism and gluconeogenesis, and of liver glycogen structure, contributing to improved hepatic glucose metabolism in diabetic mice.Graphical abstractDOP could regulate glucagon-mediated signaling pathways and reverse the instability of liver glycogen structure, contributing to improved hepatic glucose metabolism.
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Boston University researchers found that while effective in treating pain, cortisone jabs can speed up a joint's disintegration and force patients to have full knee or hip replacements.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The TV ad promises pain relief for knee osteoarthritis, the source of most of the 600,000 knee replacement surgeries performed in the US each year. A man in a bowling alley winces with pain. He nearly falls as he rolls a ball into the gutter. (Did I mention the arrow sticking out of his knee?) “Knee acting up again?” asks his buddy, clearly concerned. When pain pills don’t seem to help, his buddy suggests a procedure called Coolief for knee osteoarthritis. “I had it done six months ago,” says the bowling buddy. “And the best part is that it lasts up to one year.” What is Coolief? C...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Arthritis Bones and joints Osteoarthritis Pain Management Tests and procedures Source Type: blogs
X-ray imaging shows that corticosteroid injections for osteoarthritis pain...Read more on AuntMinnie.comRelated Reading: 3D MRI helps predict osteoarthritis risk after ACL tears 3 ways to reduce unnecessary MRI knee scans 6 ways AI will enhance musculoskeletal imaging Many knee MRI scans may not be clinically indicated New 3D CT technique tops x-ray for diagnosing arthritis
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
TUESDAY, Oct. 15, 2019 -- Corticosteroid shots are often used to ease arthritis pain, but a new study suggests they may be riskier than thought. Researchers found that among patients who had the treatment at their center, 8% had complications. Most...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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