How CareDx Is Bringing AI to Transplant Care

Brisbane, CA-based CareDx has partnered with Cibiltech, a French company that develops artificial intelligence-based products for predictive medicine, to commercialize Predigraft.  Predigraft is a data analysis tool designed to provide an early prediction of a patient's risk of allograft rejection and transplant loss. It was developed from Cibiltech’s software algorithm called iBox, which is built off the outcomes data from tens of thousands of transplant patients. The deal is yet another example of how AI is disrupting the status quo in medtech. MD+DI recently published this guide characterizing the current state of AI in the industry from technical considerations to regulatory and reimbursement challenges. CareDx now has the exclusive rights to sell Predigraft in the United States. The company also acquired a minority equity ownership of Cibiltech. The companies have also agreed to collaborate to advance the development of AI in transplant care. Financial terms of the deal were not disclosed.  The news comes on the heels of the company's recent $16 million acquisition of OTTR Complete Transplant Management, a provider of organ transplant patient tracking software. That deal is expected to close this month. "We're moving from proprietary biomarkers to multimodality testing and then we're adding to this multimodality testing our artificial intelligence component to make sure there's digital healthcare avai...
Source: MDDI - Category: Medical Devices Authors: Tags: Software Source Type: news

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CONCLUSION: Appropriate monitoring of graft function is necessary in patients with cured PTCs. PMID: 32449324 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Condition:   the Efficacy and Effect on Patient Comfort of a Hidden-knot Continuous Suture for Pterygium Excision With Conjunctival Autograft Intervention:   Procedure: suture Sponsor:   Aier School of Ophthalmology, Central South University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We describe 3 additional children from 2 unrelated families with cholestasis and liver failure because of pathologic variants in NR1H4. One patient underwent liver transplantation and has had good clinical outcomes in 6 years of follow-up. Although that patient has biochemical evidence of increased bile acid synthetic activity, he has not experienced post-transplant diarrhea or allograft steatosis, as has been reported among other transplanted patients.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Short Communication: Hepatology Source Type: research
Condition:   the Efficacy and Effect on Patient Comfort of a Hidden-knot Continuous Suture for Pterygium Excision With Conjunctival Autograft Intervention:   Procedure: suture Sponsor:   Aier School of Ophthalmology, Central South University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions. Airway instillation of LPS in allografts under immunosuppression resulted in BOS-like airway-centered inflammation and fibrosis distinct from RAS-like diffuse fibrosis, which was induced by a shortened course of immunosuppression. We propose novel animal models for BOS and RAS after lung transplantation.
Source: Transplantation - Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Conclusions. Chronic airway injury and dysregulated repair programs are evident in airway epithelium obtained from patients with BOS, particularly with SAEC. We also show that azithromycin partially mitigates this pathology.
Source: Transplantation - Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Conclusions. Blocking Nlrp3 inflammasome activation with MCC950 ameliorates OB lesions. The mechanistic analysis showed that MCC950 regulated the balance of Th1/Th17 and Treg cells and that this process is partially mediated by inhibition of IL-1β and IL-18. Therefore, targeting the Nlrp3 inflammasome is a promising strategy for controlling OB after lung transplantation.
Source: Transplantation - Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Background. Our aim was to evaluate liver transplant outcomes involving donors with high macrosteatosis grafts in the obese modern liver transplant recipient population. Methods. A high-steatosis graft was defined as donor graft macrosteatosis ≥30% on biopsy. Recipient obesity was defined as body mass index (BMI)>35 adjusted for ascites. Raw and adjusted recipient liver transplant survival were evaluated and compared between 4 cohorts: (1) high-steatosis graft in high-BMI recipient; (2) low-steatosis graft in high-BMI recipient; (3) high-steatosis graft in normal-BMI recipient; and (4) low-steatosis graft in nor...
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Background. Tacrolimus trough concentrations (mean/variability), as well as concentration-to-dose ratio (C/D ratio), affect kidney allograft outcomes. We investigated the link between the C/D ratio and death-censored kidney graft survival (DCGS). Methods. We performed a retrospective study on 1029 kidney transplant patients (2004–2016) with the following criteria: tacrolimus-based immunosuppression,>1-year graft survival, no initial use of everolimus, and available anti–human leukocyte antigen antibody data. We analyzed the impact of the time-varying C/D ratio on DCGS. Fast metabolizers were defined by a C/D ratio
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Conclusions. AKI measured using injury biomarkers was not associated with posttransplant graft outcomes (at median 4 y posttransplant). When assessing posttransplant graft viability, clinicians can prioritize other donor and recipient factors over donor kidney injury, measured by either serum creatinine or urine injury biomarkers.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
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