Tooniliatone A sensitizes multidrug resistant cancer cells by decreasing Bcl-xL via activation of JNK MAPK signaling

CONCLUSIONOur study suggests that TA reverses tumor MDR by activating the SAPK/JNK pathway to inhibit the action of Bcl-xL. TA may be an effective tumor MDR reversal agent.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research