Interferon Gamma Release Assays in Patients with Respiratory Isolates of Non-Tuberculous Mycobacteria - a Preliminary Study.

Interferon Gamma Release Assays in Patients with Respiratory Isolates of Non-Tuberculous Mycobacteria - a Preliminary Study. Pol J Microbiol. 2018;68(1):1-5 Authors: Augustynowicz-Kopeć E, Siemion-Szcześniak I, Zabost A, Wyrostkiewicz D, Filipczak D, Oniszh K, Gawryluk D, Radzikowska E, Korzybski D, Szturmowicz M Abstract Interferon gamma releasing assays (IGRAs) are extensively used in the diagnosis of latent tuberculosis infections. Comparing to tuberculin skin test (TST) they lack false positive results in the populations vaccinated with BCG, and in most non-tuberculous mycobacteria (NTM) infections. Nevertheless, Mycobacterium kansasii, Mycobacterium marinum, and Mycobacterium szulgai may induce positive IGRAs due to RD1 homology with Mycobacterium tuberculosis. The aim of the study was to investigate the possible influence of NTM respiratory isolates on the results of IGRAs. 39 patients (23 females and 16 males) of median age 61 years, with negative medical history concerning tuberculosis, entered the study. Identification of NTM was performed using the niacin test and molecular method GenoType CM test (Hain Lifescience). QFT-Plus was performed in 17 patients, T-SPOT-Tb - in 23 patients. Chest X-rays and a high-resolution computed tomography of the chest have been reviewed by the experienced radiologist blinded to the results of IGRAs, in search of past tuberculosis signs. Positive IGRAs results were obtained in three out of 39 patients (8%): 22% o...
Source: Polish Journal of Microbiology - Category: Microbiology Tags: Pol J Microbiol Source Type: research

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ConclusionSynergistic and additive effects between these two-drug combinations offer an attractive chemotherapeutic regimen against drug-resistant clinical MTB isolates.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
No abstract available
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
No abstract available
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Conclusion: PET/CT added no significant additional benefit over Chest CT in patients with suspected OS or IOTB. PMID: 31743044 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
[UCT] The Cape Universities Body Imaging Centre (CUBIC) launched its Positron Emission Tomography-Computed Tomography (PET-CT) Core Research Facility on Wednesday, 13 November, bolstering capacity in cutting-edge research on tuberculosis (TB), oncology, neurocognitive disorders, cardiovascular and other diseases.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
(University of Michigan) With a shortage of new tuberculosis drugs in the pipeline, a software tool from the University of Michigan can predict how current drugs--including unlikely candidates -- can be combined in new ways to create more effective treatments.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Publication date: Available online 20 November 2019Source: Inorganica Chimica ActaAuthor(s): Carlos M. Manzano, Douglas H. Nakahata, Juan C. Tenorio, Wilton R. Lustri, Flávia A. Resende Nogueira, Nadia A. Aleixo, Pietra S. da Silva Gomes, Fernando R. Pavan, Julia A. Grecco, Camila M. Ribeiro, Pedro P. CorbiAbstractThis manuscript presents three silver(I) complexes with fluoroanthranilic acid (fa) isomers, [Ag(4fa)]n, [Ag(5fa)]n and [Ag(6fa)]n, which were named as Ag4fa, Ag5fa and Ag6fa, respectively. The 1:1 metal/ligand molar composition of the complexes was determined by elemental, thermal and high-resolution mass...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Authors: Han D, Lee HY, Kim K, Kim T, Oh YM, Rhee CK Abstract Background: Little clinical information on high grade tuberculosis destroyed lung (TDL) is available. The aim of this study was to investigate the characteristics and healthcare utilization of high grade TDL patients, and compared the differences between acute exacerbation and healthcare burden according to inhaler compliance. Methods: This was an observational retrospective cohort study using the Korean Health Insurance Review and Assessment (HIRA) service database (2011-2015). Patients diagnosed with high grade TDL in 2011 were enrolled and reviewe...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Drug screening models have a vital role in the development of novel antimycobacterial agents which are urgently needed to tackle drug-resistant tuberculosis (TB). We recently established the larvae of the insect Galleria mellonella (greater wax moth) as a novel infection model for the Mycobacterium tuberculosis complex. Here we demonstrate its use as a rapid and reproducible screen to evaluate antimycobacterial drug efficacy using larvae infected with bioluminescent Mycobacterium bovis BCG lux. Treatment improved larval survival outcome and, with the exception of pyrazinamide, was associated with a significant reduction in...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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